Two sample MR report
Cytochrome c oxidase subunit 8A, mitochondrial against Frailty index || id:ebi-a-GCST90020053
Date: 06 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 8 | -0.0113334 | 0.0081083 | 0.2116831 |
| Weighted median | 8 | -0.0115180 | 0.0061424 | 0.0607688 |
| Inverse variance weighted | 8 | -0.0130215 | 0.0054991 | 0.0178872 |
| Simple mode | 8 | -0.0101938 | 0.0115896 | 0.4082738 |
| Weighted mode | 8 | -0.0112987 | 0.0060834 | 0.1056315 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.805349 | 6 | 0.8328510 |
| Inverse variance weighted | 2.885609 | 7 | 0.8953788 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0009065 | 0.0031998 | 0.7864663 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0160573 | 0 | TRUE | 0 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
