Two sample MR report
Kynurenine levels against Frailty index || id:ebi-a-GCST90020053
Date: 06 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 14 | 0.0065331 | 0.0379476 | 0.8661801 |
| Weighted median | 14 | 0.0435250 | 0.0136693 | 0.0014518 |
| Inverse variance weighted | 14 | 0.0430278 | 0.0106849 | 0.0000565 |
| Simple mode | 14 | 0.0207827 | 0.0213724 | 0.3485938 |
| Weighted mode | 14 | 0.0348226 | 0.0181962 | 0.0779289 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 15.16797 | 12 | 0.2323788 |
| Inverse variance weighted | 16.43766 | 13 | 0.2263014 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0048421 | 0.0048313 | 0.3360053 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0005506 | 0 | TRUE | 0.0381131 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
