Two sample MR report
1,2-dipalmitoyl-gpc (16:0/16:0) levels against Frailty index || id:ebi-a-GCST90020053
Date: 06 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 13 | 0.0804478 | 0.0328937 | 0.0324931 |
| Weighted median | 13 | 0.0676255 | 0.0120737 | 0.0000000 |
| Inverse variance weighted | 13 | 0.0564176 | 0.0137624 | 0.0000414 |
| Simple mode | 13 | 0.0589811 | 0.0208341 | 0.0151480 |
| Weighted mode | 13 | 0.0668189 | 0.0119981 | 0.0001220 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 27.78075 | 11 | 0.0034972 |
| Inverse variance weighted | 29.42507 | 12 | 0.0034056 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0034628 | 0.0042916 | 0.4368263 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0009846 | 0 | TRUE | 0.0055576 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
