Two sample MR report
Palmitoylcarnitine levels (Metabolon platform) against Frailty index || id:ebi-a-GCST90020053
Date: 06 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 17 | 0.0272973 | 0.0391245 | 0.4960359 |
| Weighted median | 17 | 0.0318968 | 0.0156629 | 0.0417045 |
| Inverse variance weighted | 17 | 0.0314603 | 0.0138642 | 0.0232576 |
| Simple mode | 17 | -0.0048890 | 0.0288989 | 0.8677785 |
| Weighted mode | 17 | 0.0352957 | 0.0236432 | 0.1549330 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 29.96278 | 15 | 0.0120564 |
| Inverse variance weighted | 29.98889 | 16 | 0.0180599 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0004899 | 0.0042851 | 0.9104953 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.000372 | 0 | TRUE | 0.089371 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
