Two sample MR report
1-stearoyl-gpc (18:0) levels against Frailty index || id:ebi-a-GCST90020053
Date: 06 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.0469163 | 0.2091627 | 0.8595277 |
| Weighted median | 3 | 0.0700978 | 0.0232022 | 0.0025180 |
| Inverse variance weighted | 3 | 0.0796800 | 0.0273655 | 0.0035948 |
| Simple mode | 3 | 0.0501187 | 0.0320031 | 0.2578283 |
| Weighted mode | 3 | 0.0596206 | 0.0283790 | 0.1704430 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 4.694803 | 1 | 0.0302540 |
| Inverse variance weighted | 4.813977 | 2 | 0.0900862 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0042452 | 0.0266448 | 0.8994165 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.000132 | 0 | TRUE | 0.3128917 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
