Two sample MR report
X-12100 levels against Frailty index || id:ebi-a-GCST90020053
Date: 06 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | 0.0786805 | 0.1135632 | 0.5600515 |
| Weighted median | 4 | 0.0533711 | 0.0274257 | 0.0516520 |
| Inverse variance weighted | 4 | 0.0594741 | 0.0226764 | 0.0087228 |
| Simple mode | 4 | 0.0265263 | 0.0450285 | 0.5972135 |
| Weighted mode | 4 | 0.0218935 | 0.0383843 | 0.6083438 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 3.625387 | 2 | 0.1632139 |
| Inverse variance weighted | 3.680482 | 3 | 0.2980975 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0021712 | 0.0124541 | 0.8776499 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 7.67e-05 | 0 | TRUE | 0.4413669 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
