Two sample MR report
Alpha-ketoglutarate to kynurenine ratio against Frailty index || id:ebi-a-GCST90020053
Date: 06 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -0.1460779 | 0.0891405 | 0.3488067 |
| Weighted median | 3 | -0.0490036 | 0.0251868 | 0.0517015 |
| Inverse variance weighted | 3 | -0.0474608 | 0.0210393 | 0.0240825 |
| Simple mode | 3 | -0.0355801 | 0.0332918 | 0.3970888 |
| Weighted mode | 3 | -0.0611434 | 0.0295188 | 0.1741326 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.1614407 | 1 | 0.6878335 |
| Inverse variance weighted | 1.4575711 | 2 | 0.4824946 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0104722 | 0.0091984 | 0.4588331 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 7.4e-05 | 0 | TRUE | 0.4463304 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
