Two sample MR report
(phylum: proteobacteria) at the forehead (sebaceous skin) against Frailty index || id:ebi-a-GCST90020053
Date: 07 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -0.0184289 | 0.0928667 | 0.8752865 |
| Weighted median | 3 | -0.0058403 | 0.0060301 | 0.3327818 |
| Inverse variance weighted | 3 | -0.0102664 | 0.0051487 | 0.0461554 |
| Simple mode | 3 | -0.0055863 | 0.0076601 | 0.5416763 |
| Weighted mode | 3 | -0.0056271 | 0.0067318 | 0.4911659 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.301430 | 1 | 0.1292549 |
| Inverse variance weighted | 2.319319 | 2 | 0.3135929 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0037504 | 0.0425383 | 0.9440176 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0196254 | 0 | TRUE | 0.0206229 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
