Two sample MR report
(asv: asv009) at the antecubital fossa (moist skin) against Frailty index || id:ebi-a-GCST90020053
Date: 07 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | 0.0003193 | 0.0120195 | 0.9804752 |
| Weighted median | 5 | -0.0071546 | 0.0041186 | 0.0823606 |
| Inverse variance weighted | 5 | -0.0062419 | 0.0030243 | 0.0390239 |
| Simple mode | 5 | -0.0078621 | 0.0054723 | 0.2241615 |
| Weighted mode | 5 | -0.0072982 | 0.0052602 | 0.2375981 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 3.295248 | 3 | 0.3483046 |
| Inverse variance weighted | 3.647015 | 4 | 0.4558791 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0042126 | 0.007444 | 0.6110226 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0513326 | 0 | TRUE | 0.0001535 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
