

# Two sample MR report

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## Type 2 diabetes || id:ebi-a-GCST90029024 against Body mass index || id:ieu-a-2

Date: **21 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|      b|    se|  pval|
|:-------------------------|----:|------:|-----:|-----:|
|MR Egger                  |   33| -1.735| 1.634| 0.297|
|Weighted median           |   33| -1.679| 0.228| 0.000|
|Inverse variance weighted |   33| -0.322| 0.758| 0.671|
|Simple mode               |   33| -1.650| 0.433| 0.001|
|Weighted mode             |   33| -1.755| 0.203| 0.000|

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### Heterogeneity tests


|method                    |   Q| Q_df| Q_pval|
|:-------------------------|---:|----:|------:|
|MR Egger                  | 915|   31|      0|
|Inverse variance weighted | 943|   32|      0|

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### Test for directional horizontal pleiotropy


| egger_intercept|    se|  pval|
|---------------:|-----:|-----:|
|           0.007| 0.007| 0.337|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|               0|              0|TRUE                     |        0.993|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Type_2_diabetes__idebiaGCST90029024_against_Body_mass_index__idieua2chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Type_2_diabetes__idebiaGCST90029024_against_Body_mass_index__idieua2chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Type_2_diabetes__idebiaGCST90029024_against_Body_mass_index__idieua2chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Type_2_diabetes__idebiaGCST90029024_against_Body_mass_index__idieua2chunk8-1.png)
