

# Two sample MR report

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## T-cell surface glycoprotein CD6 isoform levels against Presbycusis || id:finn-b-H8_HL_PRESBY

Date: **23 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    3| 0.0547833| 0.1172926| 0.7218262|
|Weighted median           |    3| 0.1364183| 0.0693701| 0.0492376|
|Inverse variance weighted |    3| 0.1410812| 0.0700147| 0.0439022|
|Simple mode               |    3| 0.3213625| 0.1564882| 0.1764021|
|Weighted mode             |    3| 0.1236365| 0.0693952| 0.2167587|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0973136|    1| 0.7550776|
|Inverse variance weighted | 0.9382969|    2| 0.6255347|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0349889| 0.0381537| 0.5275286|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0167202|              0|TRUE                     |            0|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Tcell_surface_glycoprotein_CD6_isoform_levels_against_Presbycusis__idfinnbH8HLPRESBYchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Tcell_surface_glycoprotein_CD6_isoform_levels_against_Presbycusis__idfinnbH8HLPRESBYchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Tcell_surface_glycoprotein_CD6_isoform_levels_against_Presbycusis__idfinnbH8HLPRESBYchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Tcell_surface_glycoprotein_CD6_isoform_levels_against_Presbycusis__idfinnbH8HLPRESBYchunk8-1.png)
