

# Two sample MR report

---

## NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial against Presbycusis || id:finn-b-H8_HL_PRESBY

Date: **21 February, 2026**

---

### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   18| 0.0646098| 0.0524406| 0.2357280|
|Weighted median           |   18| 0.0773944| 0.0413103| 0.0610012|
|Inverse variance weighted |   18| 0.0771681| 0.0365974| 0.0349820|
|Simple mode               |   18| 0.0570508| 0.1244297| 0.6524019|
|Weighted mode             |   18| 0.0741015| 0.0396039| 0.0786501|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 16.75318|   16| 0.4017399|
|Inverse variance weighted | 16.87572|   17| 0.4628164|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|       0.0058342| 0.017054| 0.7367289|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.1243555|              0|TRUE                     |            0|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/NADH_dehydrogenase_ubiquinone_ironsulfur_protein_4_mitochondrial_against_Presbycusis__idfinnbH8HLPRESBYchunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/NADH_dehydrogenase_ubiquinone_ironsulfur_protein_4_mitochondrial_against_Presbycusis__idfinnbH8HLPRESBYchunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/NADH_dehydrogenase_ubiquinone_ironsulfur_protein_4_mitochondrial_against_Presbycusis__idfinnbH8HLPRESBYchunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/NADH_dehydrogenase_ubiquinone_ironsulfur_protein_4_mitochondrial_against_Presbycusis__idfinnbH8HLPRESBYchunk8-1.png)
