

# Two sample MR report

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## CD62L- plasmacytoid Dendritic Cell Absolute Count against Presbycusis || id:finn-b-H8_HL_PRESBY

Date: **24 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.0068950| 0.7998126| 0.9939043|
|Weighted median           |    4|  0.3829851| 0.1325870| 0.0038701|
|Inverse variance weighted |    4|  0.3741034| 0.1767507| 0.0342973|
|Simple mode               |    4|  0.3758730| 0.1504663| 0.0878572|
|Weighted mode             |    4|  0.3837144| 0.1381305| 0.0691108|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 6.259443|    2| 0.0437300|
|Inverse variance weighted | 7.019271|    3| 0.0712861|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0877323| 0.1780554| 0.6709882|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0016536|              0|TRUE                     |    0.0204598|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CD62L_plasmacytoid_Dendritic_Cell_Absolute_Count_against_Presbycusis__idfinnbH8HLPRESBYchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CD62L_plasmacytoid_Dendritic_Cell_Absolute_Count_against_Presbycusis__idfinnbH8HLPRESBYchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CD62L_plasmacytoid_Dendritic_Cell_Absolute_Count_against_Presbycusis__idfinnbH8HLPRESBYchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CD62L_plasmacytoid_Dendritic_Cell_Absolute_Count_against_Presbycusis__idfinnbH8HLPRESBYchunk8-1.png)
