

# Two sample MR report

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## Body mass index || id:ieu-a-835 against Presbycusis || id:finn-b-H8_HL_PRESBY

Date: **21 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|      b|    se|  pval|
|:-------------------------|----:|------:|-----:|-----:|
|MR Egger                  |   67| -0.385| 0.559| 0.493|
|Weighted median           |   67| -0.221| 0.265| 0.405|
|Inverse variance weighted |   67| -0.281| 0.186| 0.131|
|Simple mode               |   67| -0.010| 0.600| 0.987|
|Weighted mode             |   67| -0.253| 0.509| 0.621|

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### Heterogeneity tests


|method                    |    Q| Q_df| Q_pval|
|:-------------------------|----:|----:|------:|
|MR Egger                  | 51.1|   65|  0.897|
|Inverse variance weighted | 51.1|   66|  0.911|

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### Test for directional horizontal pleiotropy


| egger_intercept|    se|  pval|
|---------------:|-----:|-----:|
|           0.003| 0.015| 0.844|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|               0|              0|TRUE                     |        0.452|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Body_mass_index__idieua835_against_Presbycusis__idfinnbH8HLPRESBYchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Body_mass_index__idieua835_against_Presbycusis__idfinnbH8HLPRESBYchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Body_mass_index__idieua835_against_Presbycusis__idfinnbH8HLPRESBYchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Body_mass_index__idieua835_against_Presbycusis__idfinnbH8HLPRESBYchunk8-1.png)
