

# Two sample MR report

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## CUB domain-containing protein 1 levels against Presbycusis || id:finn-b-H8_HL_PRESBY

Date: **23 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    5| 0.4071569| 0.2377912| 0.1853718|
|Weighted median           |    5| 0.2784428| 0.1306236| 0.0330362|
|Inverse variance weighted |    5| 0.2432623| 0.1122097| 0.0301643|
|Simple mode               |    5| 0.3486240| 0.1890964| 0.1390119|
|Weighted mode             |    5| 0.2897213| 0.1383310| 0.1043100|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.320896|    3| 0.5085297|
|Inverse variance weighted | 2.932027|    4| 0.5692642|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0301089| 0.0385148| 0.4913855|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0009611|              0|TRUE                     |    0.0004825|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CUB_domaincontaining_protein_1_levels_against_Presbycusis__idfinnbH8HLPRESBYchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CUB_domaincontaining_protein_1_levels_against_Presbycusis__idfinnbH8HLPRESBYchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CUB_domaincontaining_protein_1_levels_against_Presbycusis__idfinnbH8HLPRESBYchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CUB_domaincontaining_protein_1_levels_against_Presbycusis__idfinnbH8HLPRESBYchunk8-1.png)
