

# Two sample MR report

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## Superoxide dismutase [Mn],mitochondrial levels against Presbycusis || id:finn-b-H8_HL_PRESBY

Date: **21 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   14| -0.0597542| 0.0590100| 0.3312290|
|Weighted median           |   14| -0.0756387| 0.0488608| 0.1216120|
|Inverse variance weighted |   14| -0.0894076| 0.0365988| 0.0145694|
|Simple mode               |   14| -0.0721363| 0.0704309| 0.3244162|
|Weighted mode             |   14| -0.0672301| 0.0485597| 0.1895142|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 3.504865|   12| 0.9908085|
|Inverse variance weighted | 3.915246|   13| 0.9920600|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|      -0.0182542| 0.028495| 0.5338184|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0046245|              0|TRUE                     |    0.0148266|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Superoxide_dismutase_Mnmitochondrial_levels_against_Presbycusis__idfinnbH8HLPRESBYchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Superoxide_dismutase_Mnmitochondrial_levels_against_Presbycusis__idfinnbH8HLPRESBYchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Superoxide_dismutase_Mnmitochondrial_levels_against_Presbycusis__idfinnbH8HLPRESBYchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Superoxide_dismutase_Mnmitochondrial_levels_against_Presbycusis__idfinnbH8HLPRESBYchunk8-1.png)
