

# Two sample MR report

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## Body mass index || id:ieu-a-835 against Body mass index || id:ieu-a-2

Date: **21 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|     b|    se| pval|
|:-------------------------|----:|-----:|-----:|----:|
|MR Egger                  |   68| 1.002| 0.045|    0|
|Weighted median           |   68| 0.988| 0.028|    0|
|Inverse variance weighted |   68| 0.985| 0.015|    0|
|Simple mode               |   68| 0.989| 0.056|    0|
|Weighted mode             |   68| 0.991| 0.047|    0|

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### Heterogeneity tests


|method                    |    Q| Q_df| Q_pval|
|:-------------------------|----:|----:|------:|
|MR Egger                  | 3.03|   66|      1|
|Inverse variance weighted | 3.19|   67|      1|

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### Test for directional horizontal pleiotropy


| egger_intercept|    se|  pval|
|---------------:|-----:|-----:|
|               0| 0.001| 0.699|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|               0|              0|FALSE                    |        0.999|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Body_mass_index__idieua835_against_Body_mass_index__idieua2chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Body_mass_index__idieua835_against_Body_mass_index__idieua2chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Body_mass_index__idieua835_against_Body_mass_index__idieua2chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Body_mass_index__idieua835_against_Body_mass_index__idieua2chunk8-1.png)
