

# Two sample MR report

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## Calcium uptake protein 3, mitochondrial against Presbycusis || id:finn-b-H8_HL_PRESBY

Date: **21 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   16| 0.3218637| 0.2128974| 0.1528191|
|Weighted median           |   16| 0.1703083| 0.1147383| 0.1377241|
|Inverse variance weighted |   16| 0.1934274| 0.0825850| 0.0191724|
|Simple mode               |   16| 0.3501118| 0.2034032| 0.1057547|
|Weighted mode             |   16| 0.2004389| 0.1826480| 0.2897692|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 15.91065|   14| 0.3188609|
|Inverse variance weighted | 16.40095|   15| 0.3559161|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0293333| 0.0446592| 0.5219448|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0008922|              0|TRUE                     |    0.0922166|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Calcium_uptake_protein_3_mitochondrial_against_Presbycusis__idfinnbH8HLPRESBYchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Calcium_uptake_protein_3_mitochondrial_against_Presbycusis__idfinnbH8HLPRESBYchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Calcium_uptake_protein_3_mitochondrial_against_Presbycusis__idfinnbH8HLPRESBYchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Calcium_uptake_protein_3_mitochondrial_against_Presbycusis__idfinnbH8HLPRESBYchunk8-1.png)
