

# Two sample MR report

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## diastolic blood pressure || id:ieu-b-39 against Presbycusis || id:finn-b-H8_HL_PRESBY

Date: **21 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|      b|    se|  pval|
|:-------------------------|----:|------:|-----:|-----:|
|MR Egger                  |  599|  0.002| 0.025| 0.948|
|Weighted median           |  599|  0.008| 0.017| 0.629|
|Inverse variance weighted |  599|  0.014| 0.011| 0.193|
|Simple mode               |  599| -0.008| 0.051| 0.881|
|Weighted mode             |  599|  0.004| 0.033| 0.908|

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### Heterogeneity tests


|method                    |   Q| Q_df| Q_pval|
|:-------------------------|---:|----:|------:|
|MR Egger                  | 597|  597|  0.495|
|Inverse variance weighted | 597|  598|  0.503|

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### Test for directional horizontal pleiotropy


| egger_intercept|    se|  pval|
|---------------:|-----:|-----:|
|           0.002| 0.004| 0.583|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|               0|              0|TRUE                     |        0.409|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/diastolic_blood_pressure__idieub39_against_Presbycusis__idfinnbH8HLPRESBYchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/diastolic_blood_pressure__idieub39_against_Presbycusis__idfinnbH8HLPRESBYchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/diastolic_blood_pressure__idieub39_against_Presbycusis__idfinnbH8HLPRESBYchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/diastolic_blood_pressure__idieub39_against_Presbycusis__idfinnbH8HLPRESBYchunk8-1.png)
