

# Two sample MR report

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## Type 2 diabetes || id:ebi-a-GCST90029024 against Presbycusis || id:finn-b-H8_HL_PRESBY

Date: **21 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|      b|   se|  pval|
|:-------------------------|----:|------:|----:|-----:|
|MR Egger                  |   64| -3.534| 3.26| 0.283|
|Weighted median           |   64| -1.406| 2.00| 0.482|
|Inverse variance weighted |   64|  0.604| 1.42| 0.670|
|Simple mode               |   64|  1.018| 4.20| 0.809|
|Weighted mode             |   64| -1.716| 2.50| 0.496|

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### Heterogeneity tests


|method                    |    Q| Q_df| Q_pval|
|:-------------------------|----:|----:|------:|
|MR Egger                  | 75.2|   62|  0.121|
|Inverse variance weighted | 77.6|   63|  0.102|

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### Test for directional horizontal pleiotropy


| egger_intercept|    se|  pval|
|---------------:|-----:|-----:|
|           0.019| 0.014| 0.165|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|               0|              0|TRUE                     |        0.546|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Type_2_diabetes__idebiaGCST90029024_against_Presbycusis__idfinnbH8HLPRESBYchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Type_2_diabetes__idebiaGCST90029024_against_Presbycusis__idfinnbH8HLPRESBYchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Type_2_diabetes__idebiaGCST90029024_against_Presbycusis__idfinnbH8HLPRESBYchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Type_2_diabetes__idebiaGCST90029024_against_Presbycusis__idfinnbH8HLPRESBYchunk8-1.png)
