

# Two sample MR report

---

## Plasmacytoid Dendritic Cell Absolute Count against Presbycusis || id:finn-b-H8_HL_PRESBY

Date: **24 February, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.3186231| 0.8626722| 0.7473097|
|Weighted median           |    4| -0.2731655| 0.1427425| 0.0556594|
|Inverse variance weighted |    4| -0.2506205| 0.1169360| 0.0320948|
|Simple mode               |    4| -0.3064995| 0.1943653| 0.2129094|
|Weighted mode             |    4| -0.3064995| 0.1762814| 0.1804739|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.364707|    2| 0.5054262|
|Inverse variance weighted | 1.371037|    3| 0.7123377|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0122489| 0.1539539| 0.9438299|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0006535|              0|TRUE                     |    0.1448898|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Plasmacytoid_Dendritic_Cell_Absolute_Count_against_Presbycusis__idfinnbH8HLPRESBYchunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Plasmacytoid_Dendritic_Cell_Absolute_Count_against_Presbycusis__idfinnbH8HLPRESBYchunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/Plasmacytoid_Dendritic_Cell_Absolute_Count_against_Presbycusis__idfinnbH8HLPRESBYchunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Plasmacytoid_Dendritic_Cell_Absolute_Count_against_Presbycusis__idfinnbH8HLPRESBYchunk8-1.png)
