

# Two sample MR report

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## Interleukin-2 levels against Presbycusis || id:finn-b-H8_HL_PRESBY

Date: **23 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   15|  0.1634683| 0.3665877| 0.6629923|
|Weighted median           |   15| -0.4760029| 0.1938869| 0.0140863|
|Inverse variance weighted |   15| -0.3055981| 0.1394854| 0.0284592|
|Simple mode               |   15| -0.5662656| 0.3309210| 0.1091028|
|Weighted mode             |   15| -0.5500371| 0.3042564| 0.0921639|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  |  8.951616|   13| 0.7765879|
|Inverse variance weighted | 10.866021|   14| 0.6965277|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0548456| 0.0396392| 0.1897729|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.43e-05|              0|TRUE                     |    0.4593913|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Interleukin2_levels_against_Presbycusis__idfinnbH8HLPRESBYchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Interleukin2_levels_against_Presbycusis__idfinnbH8HLPRESBYchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Interleukin2_levels_against_Presbycusis__idfinnbH8HLPRESBYchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Interleukin2_levels_against_Presbycusis__idfinnbH8HLPRESBYchunk8-1.png)
