Two sample MR report
Type 2 diabetes || id:ebi-a-GCST90029024 against Presbycusis || id:finn-b-H8_HL_PRESBY
Date: 21 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 64 | -3.534 | 3.26 | 0.283 |
| Weighted median | 64 | -1.406 | 2.00 | 0.482 |
| Inverse variance weighted | 64 | 0.604 | 1.42 | 0.670 |
| Simple mode | 64 | 1.018 | 4.20 | 0.809 |
| Weighted mode | 64 | -1.716 | 2.50 | 0.496 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 75.2 | 62 | 0.121 |
| Inverse variance weighted | 77.6 | 63 | 0.102 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.019 | 0.014 | 0.165 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.546 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
