Two sample MR report
Type 2 diabetes || id:ebi-a-GCST90029024 against Body mass index || id:ieu-a-2
Date: 21 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 33 | -1.735 | 1.634 | 0.297 |
| Weighted median | 33 | -1.679 | 0.228 | 0.000 |
| Inverse variance weighted | 33 | -0.322 | 0.758 | 0.671 |
| Simple mode | 33 | -1.650 | 0.433 | 0.001 |
| Weighted mode | 33 | -1.755 | 0.203 | 0.000 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 915 | 31 | 0 |
| Inverse variance weighted | 943 | 32 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.007 | 0.007 | 0.337 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.993 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
