Two sample MR report
Body mass index || id:ieu-a-835 against Presbycusis || id:finn-b-H8_HL_PRESBY
Date: 21 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 67 | -0.385 | 0.559 | 0.493 |
| Weighted median | 67 | -0.221 | 0.265 | 0.405 |
| Inverse variance weighted | 67 | -0.281 | 0.186 | 0.131 |
| Simple mode | 67 | -0.010 | 0.600 | 0.987 |
| Weighted mode | 67 | -0.253 | 0.509 | 0.621 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 51.1 | 65 | 0.897 |
| Inverse variance weighted | 51.1 | 66 | 0.911 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.003 | 0.015 | 0.844 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.452 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
