Two sample MR report
Body mass index || id:ieu-a-835 against Presbycusis || id:finn-b-H8_HL_PRESBY
Date: 20 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 148 | -0.400 | 0.444 | 0.369 |
| Weighted median | 148 | -0.169 | 0.230 | 0.465 |
| Inverse variance weighted | 148 | -0.193 | 0.150 | 0.196 |
| Simple mode | 148 | 0.033 | 0.611 | 0.957 |
| Weighted mode | 148 | -0.206 | 0.439 | 0.639 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 134 | 146 | 0.746 |
| Inverse variance weighted | 135 | 147 | 0.760 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.005 | 0.01 | 0.622 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.453 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
