Two sample MR report
Diagnoses - secondary ICD10: I10 Essential (primary) hypertension || id:ukb-b-12493 against Hearing difficulty/problems with background noise || id:ukb-b-18275
Date: 20 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 177 | -0.019 | 0.099 | 0.846 |
| Weighted median | 177 | 0.035 | 0.030 | 0.251 |
| Inverse variance weighted | 177 | -0.008 | 0.030 | 0.791 |
| Simple mode | 177 | 0.054 | 0.097 | 0.580 |
| Weighted mode | 177 | 0.054 | 0.094 | 0.570 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 414 | 175 | 0 |
| Inverse variance weighted | 414 | 176 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0 | 0 | 0.904 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.644 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
