Two sample MR report
HDL cholesterol || id:ieu-a-299 against Hearing difficulty/problems with background noise || id:ukb-b-18275
Date: 20 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 126 | -0.011 | 0.007 | 0.137 |
| Weighted median | 126 | -0.010 | 0.005 | 0.027 |
| Inverse variance weighted | 126 | -0.003 | 0.004 | 0.454 |
| Simple mode | 126 | -0.008 | 0.008 | 0.303 |
| Weighted mode | 126 | -0.008 | 0.004 | 0.038 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 276 | 124 | 0 |
| Inverse variance weighted | 280 | 125 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0 | 0 | 0.196 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
