Two sample MR report
HDL cholesterol || id:ieu-a-299 against Presbycusis || id:finn-b-H8_HL_PRESBY
Date: 20 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 125 | -0.227 | 0.194 | 0.243 |
| Weighted median | 125 | 0.025 | 0.157 | 0.874 |
| Inverse variance weighted | 125 | -0.074 | 0.109 | 0.499 |
| Simple mode | 125 | -0.447 | 0.318 | 0.162 |
| Weighted mode | 125 | -0.023 | 0.156 | 0.882 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 160 | 123 | 0.013 |
| Inverse variance weighted | 162 | 124 | 0.013 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.007 | 0.008 | 0.34 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.002 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
