Two sample MR report
HDL cholesterol || id:ieu-a-299 against Tinnitus || id:finn-b-H8_TINNITUS
Date: 21 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 125 | -0.022 | 0.120 | 0.856 |
| Weighted median | 125 | 0.089 | 0.108 | 0.411 |
| Inverse variance weighted | 125 | 0.124 | 0.068 | 0.067 |
| Simple mode | 125 | 0.386 | 0.225 | 0.089 |
| Weighted mode | 125 | -0.026 | 0.113 | 0.816 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 130 | 123 | 0.312 |
| Inverse variance weighted | 132 | 124 | 0.285 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.007 | 0.005 | 0.145 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.002 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
