Two sample MR report
LDL cholesterol || id:ieu-a-300 against Presbycusis || id:finn-b-H8_HL_PRESBY
Date: 20 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 108 | -0.111 | 0.111 | 0.322 |
| Weighted median | 108 | 0.027 | 0.116 | 0.813 |
| Inverse variance weighted | 108 | 0.024 | 0.080 | 0.767 |
| Simple mode | 108 | -0.019 | 0.218 | 0.931 |
| Weighted mode | 108 | -0.019 | 0.109 | 0.863 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 108 | 106 | 0.432 |
| Inverse variance weighted | 111 | 107 | 0.381 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.011 | 0.006 | 0.09 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
