Two sample MR report
Systolic blood pressure, automated reading || id:ukb-b-20175 against Hearing difficulty/problems with background noise || id:ukb-b-18275
Date: 20 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 431 | -0.016 | 0.015 | 0.287 |
| Weighted median | 431 | -0.003 | 0.006 | 0.651 |
| Inverse variance weighted | 431 | -0.010 | 0.005 | 0.047 |
| Simple mode | 431 | 0.001 | 0.021 | 0.952 |
| Weighted mode | 431 | 0.001 | 0.017 | 0.940 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 903 | 429 | 0 |
| Inverse variance weighted | 904 | 430 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0 | 0 | 0.703 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.268 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
