Two sample MR report
Total cholesterol || id:ieu-a-301 against Hearing difficulty/problems with background noise || id:ukb-b-18275
Date: 21 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 122 | -0.003 | 0.005 | 0.509 |
| Weighted median | 122 | 0.001 | 0.004 | 0.713 |
| Inverse variance weighted | 122 | -0.004 | 0.003 | 0.254 |
| Simple mode | 122 | -0.005 | 0.009 | 0.588 |
| Weighted mode | 122 | -0.001 | 0.004 | 0.800 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 263 | 120 | 0 |
| Inverse variance weighted | 263 | 121 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0 | 0 | 0.929 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
