Two sample MR report
Total cholesterol || id:ieu-a-301 against Presbycusis || id:finn-b-H8_HL_PRESBY
Date: 21 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 118 | -0.065 | 0.136 | 0.633 |
| Weighted median | 118 | -0.028 | 0.131 | 0.829 |
| Inverse variance weighted | 118 | 0.016 | 0.087 | 0.855 |
| Simple mode | 118 | 0.144 | 0.243 | 0.555 |
| Weighted mode | 118 | 0.011 | 0.120 | 0.928 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 126 | 116 | 0.255 |
| Inverse variance weighted | 126 | 117 | 0.262 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.005 | 0.006 | 0.438 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.001 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
