Two sample MR report
Type 2 diabetes || id:ebi-a-GCST90029024 against Hearing difficulty/problems with background noise || id:ukb-b-18275
Date: 20 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 157 | -0.028 | 0.100 | 0.781 |
| Weighted median | 157 | 0.087 | 0.063 | 0.167 |
| Inverse variance weighted | 157 | 0.084 | 0.044 | 0.056 |
| Simple mode | 157 | 0.166 | 0.127 | 0.192 |
| Weighted mode | 157 | 0.110 | 0.072 | 0.128 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 335 | 155 | 0 |
| Inverse variance weighted | 339 | 156 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0 | 0 | 0.219 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.291 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
