Two sample MR report
Type 2 diabetes || id:ebi-a-GCST90029024 against Presbycusis || id:finn-b-H8_HL_PRESBY
Date: 20 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 154 | -2.154 | 2.46 | 0.382 |
| Weighted median | 154 | -1.449 | 1.84 | 0.430 |
| Inverse variance weighted | 154 | 0.124 | 1.07 | 0.908 |
| Simple mode | 154 | 0.137 | 4.01 | 0.973 |
| Weighted mode | 154 | -1.767 | 2.48 | 0.477 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 154 | 152 | 0.430 |
| Inverse variance weighted | 155 | 153 | 0.429 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.008 | 0.008 | 0.305 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.546 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
