Two sample MR report
CUB domain-containing protein 1 levels against Presbycusis || id:finn-b-H8_HL_PRESBY
Date: 23 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | 0.4071569 | 0.2377912 | 0.1853718 |
| Weighted median | 5 | 0.2784428 | 0.1306236 | 0.0330362 |
| Inverse variance weighted | 5 | 0.2432623 | 0.1122097 | 0.0301643 |
| Simple mode | 5 | 0.3486240 | 0.1890964 | 0.1390119 |
| Weighted mode | 5 | 0.2897213 | 0.1383310 | 0.1043100 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.320896 | 3 | 0.5085297 |
| Inverse variance weighted | 2.932027 | 4 | 0.5692642 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0301089 | 0.0385148 | 0.4913855 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0009611 | 0 | TRUE | 0.0004825 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
