Two sample MR report
Superoxide dismutase [Mn],mitochondrial levels against Presbycusis || id:finn-b-H8_HL_PRESBY
Date: 21 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 14 | -0.0597542 | 0.0590100 | 0.3312290 |
| Weighted median | 14 | -0.0756387 | 0.0488608 | 0.1216120 |
| Inverse variance weighted | 14 | -0.0894076 | 0.0365988 | 0.0145694 |
| Simple mode | 14 | -0.0721363 | 0.0704309 | 0.3244162 |
| Weighted mode | 14 | -0.0672301 | 0.0485597 | 0.1895142 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 3.504865 | 12 | 0.9908085 |
| Inverse variance weighted | 3.915246 | 13 | 0.9920600 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0182542 | 0.028495 | 0.5338184 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0046245 | 0 | TRUE | 0.0148266 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
