Two sample MR report
Calcium uptake protein 3, mitochondrial against Presbycusis || id:finn-b-H8_HL_PRESBY
Date: 21 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 16 | 0.3218637 | 0.2128974 | 0.1528191 |
| Weighted median | 16 | 0.1703083 | 0.1147383 | 0.1377241 |
| Inverse variance weighted | 16 | 0.1934274 | 0.0825850 | 0.0191724 |
| Simple mode | 16 | 0.3501118 | 0.2034032 | 0.1057547 |
| Weighted mode | 16 | 0.2004389 | 0.1826480 | 0.2897692 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 15.91065 | 14 | 0.3188609 |
| Inverse variance weighted | 16.40095 | 15 | 0.3559161 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0293333 | 0.0446592 | 0.5219448 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0008922 | 0 | TRUE | 0.0922166 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
