

# Two sample MR report

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## k__Bacteria|p__Actinobacteriota|c__Actinobacteria|o__Actinomycetales|f__Micrococcaceae|g__Rothia|s__Rothia_mucilaginosa_B_mgs_3123 against Inflammatory bowel disease || id:ebi-a-GCST004131

Date: **17 October, 2025**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3|  1.7143679| 3.3177679| 0.6963728|
|Weighted median           |    3| -0.3853229| 0.1371533| 0.0049629|
|Inverse variance weighted |    3| -0.3757974| 0.1064773| 0.0004166|
|Simple mode               |    3| -0.3855744| 0.1634283| 0.1422892|
|Weighted mode             |    3| -0.4002537| 0.1656456| 0.1369511|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0078319|    1| 0.9294809|
|Inverse variance weighted | 0.4051303|    2| 0.8166333|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.2166994| 0.3437948| 0.6419568|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0005159|              0|TRUE                     |    0.3220478|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapActinobacteriotacActinobacteriaoActinomycetalesfMicrococcaceaegRothiasRothiamucilaginosaBmgs3123_against_Inflammatory_bowel_disease__idebiaGCST004131chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapActinobacteriotacActinobacteriaoActinomycetalesfMicrococcaceaegRothiasRothiamucilaginosaBmgs3123_against_Inflammatory_bowel_disease__idebiaGCST004131chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapActinobacteriotacActinobacteriaoActinomycetalesfMicrococcaceaegRothiasRothiamucilaginosaBmgs3123_against_Inflammatory_bowel_disease__idebiaGCST004131chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapActinobacteriotacActinobacteriaoActinomycetalesfMicrococcaceaegRothiasRothiamucilaginosaBmgs3123_against_Inflammatory_bowel_disease__idebiaGCST004131chunk8-1.png)
