

# Two sample MR report

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## k__Bacteria|p__Firmicutes|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__Streptococcus_sp001553685_mgs_223 against Inflammatory bowel disease || id:finn-b-K11_IBD

Date: **17 October, 2025**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.2926133| 1.4837657| 0.8760429|
|Weighted median           |    3| -0.2844013| 0.1715755| 0.0974009|
|Inverse variance weighted |    3| -0.3049435| 0.1424902| 0.0323466|
|Simple mode               |    3| -0.2772074| 0.1890837| 0.2802823|
|Weighted mode             |    3| -0.2754437| 0.2029739| 0.3076288|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.2136681|    1| 0.6439075|
|Inverse variance weighted | 0.2137378|    2| 0.8986435|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0013513| 0.1618528| 0.9946852|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004945|              0|TRUE                     |     0.326154|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussStreptococcussp001553685mgs223_against_Inflammatory_bowel_disease__idfinnbK11IBDchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussStreptococcussp001553685mgs223_against_Inflammatory_bowel_disease__idfinnbK11IBDchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussStreptococcussp001553685mgs223_against_Inflammatory_bowel_disease__idfinnbK11IBDchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussStreptococcussp001553685mgs223_against_Inflammatory_bowel_disease__idfinnbK11IBDchunk8-1.png)
