

# Two sample MR report

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## k__Bacteria|p__Firmicutes|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Catonella|s__unclassified_mgs_2059 against Inflammatory bowel disease || id:ebi-a-GCST004131

Date: **17 October, 2025**

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### Results from two sample MR:


|method                    | nsnp|         b|         se|      pval|
|:-------------------------|----:|---------:|----------:|---------:|
|MR Egger                  |    4| 1.3073822| 10.5224644| 0.9124814|
|Weighted median           |    4| 0.1884666|  0.1077106| 0.0801617|
|Inverse variance weighted |    4| 0.1941619|  0.0874062| 0.0263256|
|Simple mode               |    4| 0.1702707|  0.1376448| 0.3040813|
|Weighted mode             |    4| 0.1862875|  0.0982137| 0.1541234|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.899344|    2| 0.3868679|
|Inverse variance weighted | 1.910537|    3| 0.5911810|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|      -0.1162783| 1.099057| 0.9253978|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0007329|              0|TRUE                     |    0.2352342|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFirmicutescClostridiaoLachnospiralesfLachnospiraceaegCatonellasunclassifiedmgs2059_against_Inflammatory_bowel_disease__idebiaGCST004131chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFirmicutescClostridiaoLachnospiralesfLachnospiraceaegCatonellasunclassifiedmgs2059_against_Inflammatory_bowel_disease__idebiaGCST004131chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFirmicutescClostridiaoLachnospiralesfLachnospiraceaegCatonellasunclassifiedmgs2059_against_Inflammatory_bowel_disease__idebiaGCST004131chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFirmicutescClostridiaoLachnospiralesfLachnospiraceaegCatonellasunclassifiedmgs2059_against_Inflammatory_bowel_disease__idebiaGCST004131chunk8-1.png)
