

# Two sample MR report

---

## k__Bacteria|p__Firmicutes|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__F0422|s__unclassified_mgs_1590 against Inflammatory bowel disease || id:finn-b-K11_IBD

Date: **17 October, 2025**

---

### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    6| 0.6190216| 1.9557138| 0.7674382|
|Weighted median           |    6| 0.2496316| 0.1201138| 0.0376825|
|Inverse variance weighted |    6| 0.2578575| 0.0980980| 0.0085745|
|Simple mode               |    6| 0.2955315| 0.1383967| 0.0858161|
|Weighted mode             |    6| 0.2349591| 0.1298315| 0.1301187|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 5.161965|    4| 0.2710789|
|Inverse variance weighted | 5.206113|    5| 0.3912474|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|    pval|
|---------------:|---------:|-------:|
|      -0.0406012| 0.2195137| 0.86226|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0009206|              0|TRUE                     |    0.1915766|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFirmicutescNegativicutesoVeillonellalesfVeillonellaceaegF0422sunclassifiedmgs1590_against_Inflammatory_bowel_disease__idfinnbK11IBDchunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFirmicutescNegativicutesoVeillonellalesfVeillonellaceaegF0422sunclassifiedmgs1590_against_Inflammatory_bowel_disease__idfinnbK11IBDchunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFirmicutescNegativicutesoVeillonellalesfVeillonellaceaegF0422sunclassifiedmgs1590_against_Inflammatory_bowel_disease__idfinnbK11IBDchunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFirmicutescNegativicutesoVeillonellalesfVeillonellaceaegF0422sunclassifiedmgs1590_against_Inflammatory_bowel_disease__idfinnbK11IBDchunk8-1.png)
