

# Two sample MR report

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## k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Bacteroidaceae|g__Prevotella|s__Prevotella_bivia_mgs_207 against Inflammatory bowel disease || id:ebi-a-GCST004131

Date: **18 October, 2025**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    3| 8.9238509| 9.7961238| 0.5296424|
|Weighted median           |    3| 0.1842905| 0.0937329| 0.0492842|
|Inverse variance weighted |    3| 0.1864180| 0.0891356| 0.0364924|
|Simple mode               |    3| 0.2484370| 0.1290860| 0.1941647|
|Weighted mode             |    3| 0.2261059| 0.1386285| 0.2444630|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.769402|    1| 0.1834561|
|Inverse variance weighted | 3.177153|    2| 0.2042162|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|      -0.9242589| 1.036201| 0.5363115|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003759|              0|TRUE                     |    0.4089345|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapBacteroidotacBacteroidiaoBacteroidalesfBacteroidaceaegPrevotellasPrevotellabiviamgs207_against_Inflammatory_bowel_disease__idebiaGCST004131chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapBacteroidotacBacteroidiaoBacteroidalesfBacteroidaceaegPrevotellasPrevotellabiviamgs207_against_Inflammatory_bowel_disease__idebiaGCST004131chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapBacteroidotacBacteroidiaoBacteroidalesfBacteroidaceaegPrevotellasPrevotellabiviamgs207_against_Inflammatory_bowel_disease__idebiaGCST004131chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapBacteroidotacBacteroidiaoBacteroidalesfBacteroidaceaegPrevotellasPrevotellabiviamgs207_against_Inflammatory_bowel_disease__idebiaGCST004131chunk8-1.png)
