

# Two sample MR report

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## k__Bacteria|p__Firmicutes|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__Streptococcus_mitis_AC_mgs_2251 against Inflammatory bowel disease || id:ebi-a-GCST004131

Date: **17 October, 2025**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    8| 2.0145993| 2.0367630| 0.3608005|
|Weighted median           |    8| 0.1065185| 0.0744354| 0.1524250|
|Inverse variance weighted |    8| 0.1141252| 0.0579964| 0.0490913|
|Simple mode               |    8| 0.1223876| 0.0975969| 0.2500914|
|Weighted mode             |    8| 0.0983448| 0.0839463| 0.2797171|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 3.683301|    6| 0.7194439|
|Inverse variance weighted | 4.554656|    7| 0.7141262|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.1963155| 0.2103086| 0.3866051|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0014798|              0|TRUE                     |    0.0922554|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussStreptococcusmitisACmgs2251_against_Inflammatory_bowel_disease__idebiaGCST004131chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussStreptococcusmitisACmgs2251_against_Inflammatory_bowel_disease__idebiaGCST004131chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussStreptococcusmitisACmgs2251_against_Inflammatory_bowel_disease__idebiaGCST004131chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussStreptococcusmitisACmgs2251_against_Inflammatory_bowel_disease__idebiaGCST004131chunk8-1.png)
