

# Two sample MR report

---

## k__Bacteria|p__Firmicutes|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__unclassified_mgs_2574 against Inflammatory bowel disease || id:finn-b-K11_IBD

Date: **17 October, 2025**

---

### Results from two sample MR:


|method                    | nsnp|         b|         se|      pval|
|:-------------------------|----:|---------:|----------:|---------:|
|MR Egger                  |    6| 9.0183721| 10.8155342| 0.4512727|
|Weighted median           |    6| 0.2055728|  0.1503038| 0.1714012|
|Inverse variance weighted |    6| 0.2771668|  0.1109206| 0.0124620|
|Simple mode               |    6| 0.2283401|  0.1713675| 0.2402058|
|Weighted mode             |    6| 0.1973763|  0.1619489| 0.2772961|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.673049|    4| 0.7956073|
|Inverse variance weighted | 2.326318|    5| 0.8023938|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|      -0.9131261| 1.129756| 0.4642724|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0007604|              0|TRUE                     |    0.2351224|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussunclassifiedmgs2574_against_Inflammatory_bowel_disease__idfinnbK11IBDchunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussunclassifiedmgs2574_against_Inflammatory_bowel_disease__idfinnbK11IBDchunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussunclassifiedmgs2574_against_Inflammatory_bowel_disease__idfinnbK11IBDchunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussunclassifiedmgs2574_against_Inflammatory_bowel_disease__idfinnbK11IBDchunk8-1.png)
