

# Two sample MR report

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## k__Bacteria|p__Firmicutes|c__Clostridia|o__Peptostreptococcales|f__Anaerovoracaceae|g__Eubacterium_M against Inflammatory bowel disease || id:ebi-a-GCST004131

Date: **17 October, 2025**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    4| 2.1873095| 2.1342139| 0.4131925|
|Weighted median           |    4| 0.1689874| 0.1192538| 0.1564714|
|Inverse variance weighted |    4| 0.2191392| 0.0905866| 0.0155584|
|Simple mode               |    4| 0.1080743| 0.1552411| 0.5364100|
|Weighted mode             |    4| 0.1876244| 0.1290305| 0.2418927|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.399248|    2| 0.4967720|
|Inverse variance weighted | 2.251234|    3| 0.5219274|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.2118371| 0.2295016| 0.453434|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0006298|              0|TRUE                     |    0.2718674|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFirmicutescClostridiaoPeptostreptococcalesfAnaerovoracaceaegEubacteriumM_against_Inflammatory_bowel_disease__idebiaGCST004131chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFirmicutescClostridiaoPeptostreptococcalesfAnaerovoracaceaegEubacteriumM_against_Inflammatory_bowel_disease__idebiaGCST004131chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFirmicutescClostridiaoPeptostreptococcalesfAnaerovoracaceaegEubacteriumM_against_Inflammatory_bowel_disease__idebiaGCST004131chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFirmicutescClostridiaoPeptostreptococcalesfAnaerovoracaceaegEubacteriumM_against_Inflammatory_bowel_disease__idebiaGCST004131chunk8-1.png)
