

# Two sample MR report

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## k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia_A|s__Leptotrichia_A_sp001274535_mgs_2052 against Inflammatory bowel disease || id:finn-b-K11_IBD

Date: **17 October, 2025**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    7| -0.5014718| 1.9228358| 0.8046488|
|Weighted median           |    7|  0.1365556| 0.1015164| 0.1785743|
|Inverse variance weighted |    7|  0.1811077| 0.0807682| 0.0249412|
|Simple mode               |    7|  0.1386810| 0.1517356| 0.3959769|
|Weighted mode             |    7|  0.1240590| 0.1453336| 0.4260784|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.072616|    5| 0.9564988|
|Inverse variance weighted | 1.198853|    6| 0.9769413|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0742425| 0.2089577| 0.7368621|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.001231|              0|TRUE                     |    0.1305041|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFusobacteriotacFusobacteriiaoFusobacterialesfLeptotrichiaceaegLeptotrichiaAsLeptotrichiaAsp001274535mgs2052_against_Inflammatory_bowel_disease__idfinnbK11IBDchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFusobacteriotacFusobacteriiaoFusobacterialesfLeptotrichiaceaegLeptotrichiaAsLeptotrichiaAsp001274535mgs2052_against_Inflammatory_bowel_disease__idfinnbK11IBDchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFusobacteriotacFusobacteriiaoFusobacterialesfLeptotrichiaceaegLeptotrichiaAsLeptotrichiaAsp001274535mgs2052_against_Inflammatory_bowel_disease__idfinnbK11IBDchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFusobacteriotacFusobacteriiaoFusobacterialesfLeptotrichiaceaegLeptotrichiaAsLeptotrichiaAsp001274535mgs2052_against_Inflammatory_bowel_disease__idfinnbK11IBDchunk8-1.png)
