

# Two sample MR report

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## k__Bacteria|p__Firmicutes|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella|s__unclassified_mgs_1671 against Inflammatory bowel disease || id:ebi-a-GCST004131

Date: **18 October, 2025**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| 11.6060277| 6.0220456| 0.1937730|
|Weighted median           |    4| -0.2540699| 0.1150481| 0.0272178|
|Inverse variance weighted |    4| -0.2687377| 0.1130047| 0.0174016|
|Simple mode               |    4| -0.4152195| 0.2018158| 0.1318220|
|Weighted mode             |    4| -0.0493064| 0.1206898| 0.7102904|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.106481|    2| 0.3488056|
|Inverse variance weighted | 6.202552|    3| 0.1021609|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       -1.219506| 0.6183923| 0.1873594|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0007826|              0|TRUE                     |    0.2324053|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFirmicutescNegativicutesoVeillonellalesfVeillonellaceaegVeillonellasunclassifiedmgs1671_against_Inflammatory_bowel_disease__idebiaGCST004131chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFirmicutescNegativicutesoVeillonellalesfVeillonellaceaegVeillonellasunclassifiedmgs1671_against_Inflammatory_bowel_disease__idebiaGCST004131chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFirmicutescNegativicutesoVeillonellalesfVeillonellaceaegVeillonellasunclassifiedmgs1671_against_Inflammatory_bowel_disease__idebiaGCST004131chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFirmicutescNegativicutesoVeillonellalesfVeillonellaceaegVeillonellasunclassifiedmgs1671_against_Inflammatory_bowel_disease__idebiaGCST004131chunk8-1.png)
