

# Two sample MR report

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## k__Bacteria|p__Firmicutes|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__F0422|s__unclassified_mgs_2118 against Inflammatory bowel disease || id:ebi-a-GCST004131

Date: **18 October, 2025**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5| -0.6733462| 2.8095455| 0.8260327|
|Weighted median           |    5| -0.1817614| 0.1217664| 0.1355143|
|Inverse variance weighted |    5| -0.2403582| 0.0921592| 0.0091052|
|Simple mode               |    5| -0.0877909| 0.1744644| 0.6412679|
|Weighted mode             |    5| -0.1689263| 0.1429145| 0.3026690|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 5.594210|    3| 0.1331112|
|Inverse variance weighted | 5.638562|    4| 0.2278156|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0480073| 0.3112852| 0.8872249|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0007692|              0|TRUE                     |    0.2376341|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFirmicutescNegativicutesoVeillonellalesfVeillonellaceaegF0422sunclassifiedmgs2118_against_Inflammatory_bowel_disease__idebiaGCST004131chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFirmicutescNegativicutesoVeillonellalesfVeillonellaceaegF0422sunclassifiedmgs2118_against_Inflammatory_bowel_disease__idebiaGCST004131chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFirmicutescNegativicutesoVeillonellalesfVeillonellaceaegF0422sunclassifiedmgs2118_against_Inflammatory_bowel_disease__idebiaGCST004131chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFirmicutescNegativicutesoVeillonellalesfVeillonellaceaegF0422sunclassifiedmgs2118_against_Inflammatory_bowel_disease__idebiaGCST004131chunk8-1.png)
