Two sample MR report
k__Bacteria|p__Firmicutes|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__unclassified_mgs_2574 against Inflammatory bowel disease || id:finn-b-K11_IBD
Date: 17 October, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 9.0183721 | 10.8155342 | 0.4512727 |
| Weighted median | 6 | 0.2055728 | 0.1503038 | 0.1714012 |
| Inverse variance weighted | 6 | 0.2771668 | 0.1109206 | 0.0124620 |
| Simple mode | 6 | 0.2283401 | 0.1713675 | 0.2402058 |
| Weighted mode | 6 | 0.1973763 | 0.1619489 | 0.2772961 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.673049 | 4 | 0.7956073 |
| Inverse variance weighted | 2.326318 | 5 | 0.8023938 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.9131261 | 1.129756 | 0.4642724 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0007604 | 0 | TRUE | 0.2351224 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
