Two sample MR report
k__Bacteria|p__Firmicutes|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella|s__unclassified_mgs_1671 against Inflammatory bowel disease || id:ebi-a-GCST004131
Date: 18 October, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | 11.6060277 | 6.0220456 | 0.1937730 |
| Weighted median | 4 | -0.2540699 | 0.1150481 | 0.0272178 |
| Inverse variance weighted | 4 | -0.2687377 | 0.1130047 | 0.0174016 |
| Simple mode | 4 | -0.4152195 | 0.2018158 | 0.1318220 |
| Weighted mode | 4 | -0.0493064 | 0.1206898 | 0.7102904 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.106481 | 2 | 0.3488056 |
| Inverse variance weighted | 6.202552 | 3 | 0.1021609 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -1.219506 | 0.6183923 | 0.1873594 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0007826 | 0 | TRUE | 0.2324053 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
