Two sample MR report
k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Bacteroidaceae|g__Prevotella|s__Prevotella_bivia_mgs_207 against Inflammatory bowel disease || id:ebi-a-GCST004131
Date: 18 October, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 8.9238509 | 9.7961238 | 0.5296424 |
| Weighted median | 3 | 0.1842905 | 0.0937329 | 0.0492842 |
| Inverse variance weighted | 3 | 0.1864180 | 0.0891356 | 0.0364924 |
| Simple mode | 3 | 0.2484370 | 0.1290860 | 0.1941647 |
| Weighted mode | 3 | 0.2261059 | 0.1386285 | 0.2444630 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.769402 | 1 | 0.1834561 |
| Inverse variance weighted | 3.177153 | 2 | 0.2042162 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.9242589 | 1.036201 | 0.5363115 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003759 | 0 | TRUE | 0.4089345 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
