Two sample MR report
k__Bacteria|p__Firmicutes|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__F0422|s__unclassified_mgs_2118 against Inflammatory bowel disease || id:ebi-a-GCST004131
Date: 18 October, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | -0.6733462 | 2.8095455 | 0.8260327 |
| Weighted median | 5 | -0.1817614 | 0.1217664 | 0.1355143 |
| Inverse variance weighted | 5 | -0.2403582 | 0.0921592 | 0.0091052 |
| Simple mode | 5 | -0.0877909 | 0.1744644 | 0.6412679 |
| Weighted mode | 5 | -0.1689263 | 0.1429145 | 0.3026690 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 5.594210 | 3 | 0.1331112 |
| Inverse variance weighted | 5.638562 | 4 | 0.2278156 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0480073 | 0.3112852 | 0.8872249 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0007692 | 0 | TRUE | 0.2376341 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
