Two sample MR report
k__Bacteria|p__Actinobacteriota|c__Actinobacteria|o__Actinomycetales|f__Micrococcaceae|g__Rothia|s__Rothia_mucilaginosa_B_mgs_3123 against Inflammatory bowel disease || id:ebi-a-GCST004131
Date: 17 October, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 1.7143679 | 3.3177679 | 0.6963728 |
| Weighted median | 3 | -0.3853229 | 0.1371533 | 0.0049629 |
| Inverse variance weighted | 3 | -0.3757974 | 0.1064773 | 0.0004166 |
| Simple mode | 3 | -0.3855744 | 0.1634283 | 0.1422892 |
| Weighted mode | 3 | -0.4002537 | 0.1656456 | 0.1369511 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0078319 | 1 | 0.9294809 |
| Inverse variance weighted | 0.4051303 | 2 | 0.8166333 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.2166994 | 0.3437948 | 0.6419568 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0005159 | 0 | TRUE | 0.3220478 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
