Two sample MR report
k__Bacteria|p__Actinobacteriota|c__Actinobacteria|o__Actinomycetales|f__Micrococcaceae|g__Rothia|s__Rothia_mucilaginosa_B_mgs_3123 against Inflammatory bowel disease || id:finn-b-K11_IBD
Date: 17 October, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | 5.0488155 | 5.5409443 | 0.4583822 |
| Weighted median | 4 | -0.3108806 | 0.1930182 | 0.1072607 |
| Inverse variance weighted | 4 | -0.3055586 | 0.1484939 | 0.0396172 |
| Simple mode | 4 | -0.1753639 | 0.2743755 | 0.5681883 |
| Weighted mode | 4 | -0.4193717 | 0.2494597 | 0.1913307 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.7403532 | 2 | 0.6906124 |
| Inverse variance weighted | 1.6748157 | 3 | 0.6425473 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.5555069 | 0.5746568 | 0.4356914 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0005159 | 0 | TRUE | 0.3166024 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
