Two sample MR report
k__Bacteria|p__Firmicutes|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__unclassified_mgs_990 against Inflammatory bowel disease || id:ebi-a-GCST004131
Date: 17 October, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | 2.1674571 | 7.1824838 | 0.7913146 |
| Weighted median | 4 | -0.1855270 | 0.0857028 | 0.0304052 |
| Inverse variance weighted | 4 | -0.1512103 | 0.0771424 | 0.0499790 |
| Simple mode | 4 | -0.2350861 | 0.1292495 | 0.1665108 |
| Weighted mode | 4 | -0.2380452 | 0.1355605 | 0.1773480 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 3.958485 | 2 | 0.1381738 |
| Inverse variance weighted | 4.164785 | 3 | 0.2442113 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.2467052 | 0.7641504 | 0.7774371 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0006406 | 0 | TRUE | 0.2673379 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
