Two sample MR report
k__Bacteria|p__Firmicutes|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__Streptococcus_mitis_AC_mgs_2251 against Inflammatory bowel disease || id:ebi-a-GCST004131
Date: 17 October, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 8 | 2.0145993 | 2.0367630 | 0.3608005 |
| Weighted median | 8 | 0.1065185 | 0.0744354 | 0.1524250 |
| Inverse variance weighted | 8 | 0.1141252 | 0.0579964 | 0.0490913 |
| Simple mode | 8 | 0.1223876 | 0.0975969 | 0.2500914 |
| Weighted mode | 8 | 0.0983448 | 0.0839463 | 0.2797171 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 3.683301 | 6 | 0.7194439 |
| Inverse variance weighted | 4.554656 | 7 | 0.7141262 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1963155 | 0.2103086 | 0.3866051 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0014798 | 0 | TRUE | 0.0922554 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
