Two sample MR report
k__Bacteria|p__Firmicutes|c__Clostridia|o__Peptostreptococcales|f__Anaerovoracaceae|g__Eubacterium_M against Inflammatory bowel disease || id:ebi-a-GCST004131
Date: 17 October, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | 2.1873095 | 2.1342139 | 0.4131925 |
| Weighted median | 4 | 0.1689874 | 0.1192538 | 0.1564714 |
| Inverse variance weighted | 4 | 0.2191392 | 0.0905866 | 0.0155584 |
| Simple mode | 4 | 0.1080743 | 0.1552411 | 0.5364100 |
| Weighted mode | 4 | 0.1876244 | 0.1290305 | 0.2418927 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.399248 | 2 | 0.4967720 |
| Inverse variance weighted | 2.251234 | 3 | 0.5219274 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.2118371 | 0.2295016 | 0.453434 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0006298 | 0 | TRUE | 0.2718674 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
