Two sample MR report
k__Bacteria|p__Firmicutes|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Catonella|s__unclassified_mgs_2059 against Inflammatory bowel disease || id:ebi-a-GCST004131
Date: 17 October, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | 1.3073822 | 10.5224644 | 0.9124814 |
| Weighted median | 4 | 0.1884666 | 0.1077106 | 0.0801617 |
| Inverse variance weighted | 4 | 0.1941619 | 0.0874062 | 0.0263256 |
| Simple mode | 4 | 0.1702707 | 0.1376448 | 0.3040813 |
| Weighted mode | 4 | 0.1862875 | 0.0982137 | 0.1541234 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.899344 | 2 | 0.3868679 |
| Inverse variance weighted | 1.910537 | 3 | 0.5911810 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1162783 | 1.099057 | 0.9253978 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0007329 | 0 | TRUE | 0.2352342 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
