Two sample MR report
k__Bacteria|p__Firmicutes|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__Streptococcus_sp001553685_mgs_223 against Inflammatory bowel disease || id:finn-b-K11_IBD
Date: 17 October, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -0.2926133 | 1.4837657 | 0.8760429 |
| Weighted median | 3 | -0.2844013 | 0.1715755 | 0.0974009 |
| Inverse variance weighted | 3 | -0.3049435 | 0.1424902 | 0.0323466 |
| Simple mode | 3 | -0.2772074 | 0.1890837 | 0.2802823 |
| Weighted mode | 3 | -0.2754437 | 0.2029739 | 0.3076288 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.2136681 | 1 | 0.6439075 |
| Inverse variance weighted | 0.2137378 | 2 | 0.8986435 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0013513 | 0.1618528 | 0.9946852 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004945 | 0 | TRUE | 0.326154 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
