

# Two sample MR report

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## Triglycerides in very small VLDL against Malignant_melanoma_of_skin

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   19| 0.2788532| 0.1384577| 0.0601153|
|Weighted median           |   19| 0.1459655| 0.0727807| 0.0449041|
|Inverse variance weighted |   19| 0.1063337| 0.0495572| 0.0318987|
|Simple mode               |   19| 0.1441387| 0.1304909| 0.2838853|
|Weighted mode             |   19| 0.2086070| 0.1258384| 0.1146958|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 12.91056|   17| 0.7421527|
|Inverse variance weighted | 14.69121|   18| 0.6830490|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0220787| 0.0165457| 0.1996685|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003487|              0|TRUE                     |     0.018217|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Triglycerides_in_very_small_VLDL_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Triglycerides_in_very_small_VLDL_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Triglycerides_in_very_small_VLDL_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Triglycerides_in_very_small_VLDL_against_Malignantmelanomaofskinchunk8-1.png)
