

# Two sample MR report

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## Total cholesterol in medium VLDL against Malignant_melanoma_of_skin

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   15| 0.2587685| 0.1542487| 0.1172885|
|Weighted median           |   15| 0.2262406| 0.0791911| 0.0042781|
|Inverse variance weighted |   15| 0.1497970| 0.0569665| 0.0085494|
|Simple mode               |   15| 0.2448163| 0.1402232| 0.1027234|
|Weighted mode             |   15| 0.2751205| 0.0972339| 0.0133807|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 14.28729|   13| 0.3539271|
|Inverse variance weighted | 14.92555|   14| 0.3832628|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0137293| 0.0180158| 0.4596218|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002913|              0|TRUE                     |    0.0257096|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Total_cholesterol_in_medium_VLDL_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Total_cholesterol_in_medium_VLDL_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Total_cholesterol_in_medium_VLDL_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Total_cholesterol_in_medium_VLDL_against_Malignantmelanomaofskinchunk8-1.png)
