

# Two sample MR report

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## 1-(1-enyl-palmitoyl)-2-palmitoyl-GPC (P-16:0/16:0) levels against Malignant_melanoma_of_skin

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    7| -0.0767249| 0.0963144| 0.4618101|
|Weighted median           |    7| -0.1058378| 0.0498614| 0.0337841|
|Inverse variance weighted |    7| -0.0869196| 0.0430995| 0.0437246|
|Simple mode               |    7| -0.0826488| 0.0802120| 0.3425650|
|Weighted mode             |    7| -0.1048059| 0.0518462| 0.0897167|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 6.319170|    5| 0.2763892|
|Inverse variance weighted | 6.337791|    6| 0.3864331|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.0021303| 0.0175501| 0.908115|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0044801|              0|TRUE                     |            0|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/11enylpalmitoyl2palmitoylGPC_P160160_levels_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/11enylpalmitoyl2palmitoylGPC_P160160_levels_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/11enylpalmitoyl2palmitoylGPC_P160160_levels_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/11enylpalmitoyl2palmitoylGPC_P160160_levels_against_Malignantmelanomaofskinchunk8-1.png)
