

# Two sample MR report

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## Orotidine levels against Malignant_melanoma_of_skin

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.0970372| 0.0486205| 0.2957016|
|Weighted median           |    3| -0.0881801| 0.0386340| 0.0224628|
|Inverse variance weighted |    3| -0.0818487| 0.0382824| 0.0325146|
|Simple mode               |    3| -0.1166440| 0.0811609| 0.2872173|
|Weighted mode             |    3| -0.0915780| 0.0393557| 0.1454460|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.251470|    1| 0.2632719|
|Inverse variance weighted | 1.796324|    2| 0.4073177|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0131882| 0.0199873| 0.6286902|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0296014|              0|TRUE                     |            0|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Orotidine_levels_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Orotidine_levels_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Orotidine_levels_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Orotidine_levels_against_Malignantmelanomaofskinchunk8-1.png)
