

# Two sample MR report

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## Triacylglycerol (54:5) levels against Malignant_melanoma_of_skin

Date: **04 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    4| 0.3488100| 0.2415732| 0.2855847|
|Weighted median           |    4| 0.2423394| 0.0836674| 0.0037740|
|Inverse variance weighted |    4| 0.2527281| 0.0740675| 0.0006446|
|Simple mode               |    4| 0.1851381| 0.1278829| 0.2435156|
|Weighted mode             |    4| 0.2415058| 0.0917246| 0.0781274|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.902060|    2| 0.2343288|
|Inverse variance weighted | 3.165679|    3| 0.3667793|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0164627| 0.0386235| 0.7114273|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004396|              0|TRUE                     |    0.0883968|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Triacylglycerol_545_levels_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Triacylglycerol_545_levels_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Triacylglycerol_545_levels_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Triacylglycerol_545_levels_against_Malignantmelanomaofskinchunk8-1.png)
