

# Two sample MR report

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## Phospholipids in medium VLDL against Malignant_melanoma_of_skin

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   14| 0.2167441| 0.1634305| 0.2094571|
|Weighted median           |   14| 0.2356755| 0.0811862| 0.0036972|
|Inverse variance weighted |   14| 0.1752123| 0.0653962| 0.0073789|
|Simple mode               |   14| 0.2688111| 0.1666798| 0.1308018|
|Weighted mode             |   14| 0.2860326| 0.1042502| 0.0167377|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 16.10875|   12| 0.1863056|
|Inverse variance weighted | 16.21350|   13| 0.2377931|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0049754| 0.0178118| 0.7847454|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002743|              0|TRUE                     |    0.0304225|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Phospholipids_in_medium_VLDL_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Phospholipids_in_medium_VLDL_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Phospholipids_in_medium_VLDL_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Phospholipids_in_medium_VLDL_against_Malignantmelanomaofskinchunk8-1.png)
