

# Two sample MR report

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## Triacylglycerol (53:3) levels against Malignant_melanoma_of_skin

Date: **04 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    6| 0.4011198| 0.1700212| 0.0777279|
|Weighted median           |    6| 0.2156406| 0.0792386| 0.0065004|
|Inverse variance weighted |    6| 0.1923191| 0.0611060| 0.0016478|
|Simple mode               |    6| 0.1820943| 0.1106406| 0.1607198|
|Weighted mode             |    6| 0.2300778| 0.0883409| 0.0479916|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 3.086424|    4| 0.5434681|
|Inverse variance weighted | 4.818331|    5| 0.4384514|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0341174| 0.0259247| 0.2585188|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0005963|              0|TRUE                     |      0.04738|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Triacylglycerol_533_levels_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Triacylglycerol_533_levels_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Triacylglycerol_533_levels_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Triacylglycerol_533_levels_against_Malignantmelanomaofskinchunk8-1.png)
