

# Two sample MR report

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## Hypotaurine to taurine ratio against Malignant_melanoma_of_skin

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3|  1.6627588| 1.2693220| 0.4150834|
|Weighted median           |    3| -0.3551585| 0.1518561| 0.0193467|
|Inverse variance weighted |    3| -0.2902188| 0.1421119| 0.0411332|
|Simple mode               |    3| -0.4558546| 0.2318496| 0.1881867|
|Weighted mode             |    3| -0.4547954| 0.2430952| 0.2022722|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.2170201|    1| 0.6413199|
|Inverse variance weighted | 2.6072899|    2| 0.2715402|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.1763924| 0.1140923| 0.365502|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.93e-05|              0|TRUE                     |    0.5067306|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Hypotaurine_to_taurine_ratio_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Hypotaurine_to_taurine_ratio_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Hypotaurine_to_taurine_ratio_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Hypotaurine_to_taurine_ratio_against_Malignantmelanomaofskinchunk8-1.png)
