

# Two sample MR report

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## Free cholesterol in large VLDL against Malignant_melanoma_of_skin

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   10| 0.4013226| 0.2378606| 0.1300428|
|Weighted median           |   10| 0.2241947| 0.0941328| 0.0172336|
|Inverse variance weighted |   10| 0.1767955| 0.0819320| 0.0309408|
|Simple mode               |   10| 0.2239900| 0.1812549| 0.2478250|
|Weighted mode             |   10| 0.2831398| 0.1179466| 0.0398603|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 10.93770|    8| 0.2052540|
|Inverse variance weighted | 12.31971|    9| 0.1958798|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0288859| 0.0287309| 0.3441444|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001744|              0|TRUE                     |    0.0838837|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Free_cholesterol_in_large_VLDL_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Free_cholesterol_in_large_VLDL_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Free_cholesterol_in_large_VLDL_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Free_cholesterol_in_large_VLDL_against_Malignantmelanomaofskinchunk8-1.png)
