

# Two sample MR report

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## Triglycerides in medium VLDL against Malignant_melanoma_of_skin

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   12| 0.2003936| 0.1689806| 0.2630759|
|Weighted median           |   12| 0.2326605| 0.0894590| 0.0093020|
|Inverse variance weighted |   12| 0.1706439| 0.0648845| 0.0085394|
|Simple mode               |   12| 0.2469137| 0.1571562| 0.1444516|
|Weighted mode             |   12| 0.2766602| 0.1128095| 0.0321057|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 11.49706|   10| 0.3201244|
|Inverse variance weighted | 11.53957|   11| 0.3992274|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0038231| 0.0198838| 0.8513778|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002287|              0|TRUE                     |    0.0491481|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Triglycerides_in_medium_VLDL_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Triglycerides_in_medium_VLDL_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Triglycerides_in_medium_VLDL_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Triglycerides_in_medium_VLDL_against_Malignantmelanomaofskinchunk8-1.png)
