

# Two sample MR report

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## Dihydroorotate levels against Malignant_melanoma_of_skin

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    7| 0.0784327| 0.1299581| 0.5724917|
|Weighted median           |    7| 0.1002968| 0.0590395| 0.0893553|
|Inverse variance weighted |    7| 0.1225141| 0.0495524| 0.0134204|
|Simple mode               |    7| 0.1816746| 0.0919798| 0.0956639|
|Weighted mode             |    7| 0.0960492| 0.0639512| 0.1838006|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.228932|    5| 0.8166461|
|Inverse variance weighted | 2.363559|    6| 0.8834141|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0089485| 0.0243884| 0.7286982|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0019081|              0|TRUE                     |    0.0001448|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Dihydroorotate_levels_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Dihydroorotate_levels_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Dihydroorotate_levels_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Dihydroorotate_levels_against_Malignantmelanomaofskinchunk8-1.png)
