

# Two sample MR report

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## Triacylglycerol (53:4) levels against Malignant_melanoma_of_skin

Date: **04 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    4| 0.3918249| 0.1934310| 0.1800562|
|Weighted median           |    4| 0.1885148| 0.0814544| 0.0206480|
|Inverse variance weighted |    4| 0.2030808| 0.0693565| 0.0034107|
|Simple mode               |    4| 0.1663985| 0.1257030| 0.2774196|
|Weighted mode             |    4| 0.2511336| 0.0980045| 0.0830353|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0947469|    2| 0.9537312|
|Inverse variance weighted | 1.1873433|    3| 0.7560415|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0329427| 0.0315159| 0.4056144|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0005124|              0|TRUE                     |    0.0784905|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Triacylglycerol_534_levels_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Triacylglycerol_534_levels_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Triacylglycerol_534_levels_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Triacylglycerol_534_levels_against_Malignantmelanomaofskinchunk8-1.png)
