

# Two sample MR report

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## X-12063 against Malignant_melanoma_of_skin

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    6| 0.2031213| 0.1877082| 0.3400783|
|Weighted median           |    6| 0.2517590| 0.1326819| 0.0577668|
|Inverse variance weighted |    6| 0.2778361| 0.1185041| 0.0190513|
|Simple mode               |    6| 0.1950754| 0.1987993| 0.3715246|
|Weighted mode             |    6| 0.2466290| 0.1356812| 0.1287881|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.9545604|    4| 0.9166060|
|Inverse variance weighted | 1.2179861|    5| 0.9431402|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0083211| 0.0162125| 0.6348234|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0069243|              0|TRUE                     |            0|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/X12063_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/X12063_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/X12063_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/X12063_against_Malignantmelanomaofskinchunk8-1.png)
