

# Two sample MR report

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## 1-(1-enyl-palmitoyl)-2-palmitoleoyl-GPC (P-16:0/16:1) levels against Malignant_melanoma_of_skin

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6| -0.1329878| 0.0950337| 0.2342737|
|Weighted median           |    6| -0.1184701| 0.0546148| 0.0300680|
|Inverse variance weighted |    6| -0.1122484| 0.0478605| 0.0190105|
|Simple mode               |    6| -0.1302560| 0.0883585| 0.2004387|
|Weighted mode             |    6| -0.1208507| 0.0597541| 0.0990581|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.365827|    4| 0.6688115|
|Inverse variance weighted | 2.429636|    5| 0.7870527|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0042388| 0.0167804| 0.8130237|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.003769|              0|TRUE                     |        1e-07|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/11enylpalmitoyl2palmitoleoylGPC_P160161_levels_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/11enylpalmitoyl2palmitoleoylGPC_P160161_levels_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/11enylpalmitoyl2palmitoleoylGPC_P160161_levels_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/11enylpalmitoyl2palmitoleoylGPC_P160161_levels_against_Malignantmelanomaofskinchunk8-1.png)
