

# Two sample MR report

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## Acisoga levels against Malignant_melanoma_of_skin

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6| -0.1197167| 0.1665409| 0.5119918|
|Weighted median           |    6| -0.1153468| 0.0725229| 0.1117248|
|Inverse variance weighted |    6| -0.1456861| 0.0584936| 0.0127515|
|Simple mode               |    6| -0.1062568| 0.1077473| 0.3693375|
|Weighted mode             |    6| -0.0963797| 0.0952407| 0.3579946|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 5.776185|    4| 0.2164980|
|Inverse variance weighted | 5.817645|    5| 0.3243692|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       -0.005501| 0.0324653| 0.8736721|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0007904|              0|TRUE                     |    0.0192594|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Acisoga_levels_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Acisoga_levels_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Acisoga_levels_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Acisoga_levels_against_Malignantmelanomaofskinchunk8-1.png)
