

# Two sample MR report

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## Free cholesterol in medium VLDL against Malignant_melanoma_of_skin

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   11| 0.2851670| 0.1722088| 0.1321170|
|Weighted median           |   11| 0.2644034| 0.0849450| 0.0018542|
|Inverse variance weighted |   11| 0.2016108| 0.0685872| 0.0032876|
|Simple mode               |   11| 0.2415545| 0.1492014| 0.1365205|
|Weighted mode             |   11| 0.2760359| 0.1133485| 0.0351312|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 11.72044|    9| 0.2295325|
|Inverse variance weighted | 12.09020|   10| 0.2790653|

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### Test for directional horizontal pleiotropy


| egger_intercept|      se|      pval|
|---------------:|-------:|---------:|
|      -0.0102361| 0.01921| 0.6070378|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002698|              0|TRUE                     |    0.0307205|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Free_cholesterol_in_medium_VLDL_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Free_cholesterol_in_medium_VLDL_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Free_cholesterol_in_medium_VLDL_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Free_cholesterol_in_medium_VLDL_against_Malignantmelanomaofskinchunk8-1.png)
