

# Two sample MR report

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## 21-hydroxypregnenolone disulfate levels against Malignant_melanoma_of_skin

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    8| 0.0113062| 0.1747192| 0.9505067|
|Weighted median           |    8| 0.0864278| 0.0652389| 0.1852409|
|Inverse variance weighted |    8| 0.1045016| 0.0527120| 0.0474231|
|Simple mode               |    8| 0.0630610| 0.0946913| 0.5267638|
|Weighted mode             |    8| 0.0896280| 0.0793225| 0.2957363|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.828447|    6| 0.9347808|
|Inverse variance weighted | 2.141453|    7| 0.9515979|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|       0.0166202| 0.029707| 0.5960916|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0006663|              0|TRUE                     |    0.0254001|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/21hydroxypregnenolone_disulfate_levels_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/21hydroxypregnenolone_disulfate_levels_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/21hydroxypregnenolone_disulfate_levels_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/21hydroxypregnenolone_disulfate_levels_against_Malignantmelanomaofskinchunk8-1.png)
