

# Two sample MR report

---

## X-21286 levels against Malignant_melanoma_of_skin

Date: **03 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.2375343| 0.6532573| 0.7509845|
|Weighted median           |    4| -0.2179515| 0.1177822| 0.0642468|
|Inverse variance weighted |    4| -0.2467928| 0.0937822| 0.0084996|
|Simple mode               |    4| -0.1241101| 0.1690913| 0.5161207|
|Weighted mode             |    4| -0.2062916| 0.1353296| 0.2248163|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 3.073769|    2| 0.2150501|
|Inverse variance weighted | 3.074087|    3| 0.3803428|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0010097| 0.0701321| 0.9898202|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001491|              0|TRUE                     |    0.2898484|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/X21286_levels_against_Malignantmelanomaofskinchunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/X21286_levels_against_Malignantmelanomaofskinchunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/X21286_levels_against_Malignantmelanomaofskinchunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/X21286_levels_against_Malignantmelanomaofskinchunk8-1.png)
