

# Two sample MR report

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## Triacylglycerol (58:7) levels against Malignant_melanoma_of_skin

Date: **04 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    6| 0.4986779| 0.2481104| 0.1148117|
|Weighted median           |    6| 0.1095196| 0.0829244| 0.1865962|
|Inverse variance weighted |    6| 0.1378883| 0.0659283| 0.0364842|
|Simple mode               |    6| 0.1100761| 0.1255608| 0.4207800|
|Weighted mode             |    6| 0.1040869| 0.1197112| 0.4243473|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 3.662729|    4| 0.4535700|
|Inverse variance weighted | 5.911579|    5| 0.3149179|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0556397| 0.0371026| 0.2080942|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004493|              0|TRUE                     |    0.1306094|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Triacylglycerol_587_levels_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Triacylglycerol_587_levels_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Triacylglycerol_587_levels_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Triacylglycerol_587_levels_against_Malignantmelanomaofskinchunk8-1.png)
