

# Two sample MR report

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## Concentration of large VLDL particles against Malignant_melanoma_of_skin

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   10| 0.1274372| 0.2060649| 0.5534860|
|Weighted median           |   10| 0.2607674| 0.0944856| 0.0057826|
|Inverse variance weighted |   10| 0.1983916| 0.0771108| 0.0100875|
|Simple mode               |   10| 0.2641422| 0.1684614| 0.1513327|
|Weighted mode             |   10| 0.2926778| 0.1125251| 0.0286911|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 11.12972|    8| 0.1944570|
|Inverse variance weighted | 11.32488|    9| 0.2540957|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0085873| 0.0229274| 0.7177344|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002093|              0|TRUE                     |    0.0696277|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Concentration_of_large_VLDL_particles_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Concentration_of_large_VLDL_particles_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Concentration_of_large_VLDL_particles_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Concentration_of_large_VLDL_particles_against_Malignantmelanomaofskinchunk8-1.png)
