

# Two sample MR report

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## Diacylglycerol (18:1_18:1) levels against Malignant_melanoma_of_skin

Date: **04 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    5| 0.2278977| 0.1986755| 0.3345355|
|Weighted median           |    5| 0.2660430| 0.0878299| 0.0024531|
|Inverse variance weighted |    5| 0.2961734| 0.0690335| 0.0000178|
|Simple mode               |    5| 0.2339904| 0.1136193| 0.1085233|
|Weighted mode             |    5| 0.2535933| 0.1021263| 0.0679823|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.181912|    3| 0.5355200|
|Inverse variance weighted | 2.316226|    4| 0.6778163|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|       0.0112892| 0.0308036| 0.738322|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004315|              0|TRUE                     |     0.097306|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Diacylglycerol_181181_levels_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Diacylglycerol_181181_levels_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Diacylglycerol_181181_levels_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Diacylglycerol_181181_levels_against_Malignantmelanomaofskinchunk8-1.png)
