

# Two sample MR report

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## Triacylglycerol (54:4) levels against Malignant_melanoma_of_skin

Date: **04 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    6| 0.2967664| 0.1488580| 0.1169657|
|Weighted median           |    6| 0.2228301| 0.0769732| 0.0037927|
|Inverse variance weighted |    6| 0.1744305| 0.0613321| 0.0044547|
|Simple mode               |    6| 0.0377966| 0.1401878| 0.7982304|
|Weighted mode             |    6| 0.2218663| 0.0825319| 0.0433895|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 4.223992|    4| 0.3765397|
|Inverse variance weighted | 5.089669|    5| 0.4050353|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|      -0.0193206| 0.021339| 0.4164521|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0006847|              0|TRUE                     |    0.0329747|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Triacylglycerol_544_levels_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Triacylglycerol_544_levels_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Triacylglycerol_544_levels_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Triacylglycerol_544_levels_against_Malignantmelanomaofskinchunk8-1.png)
