

# Two sample MR report

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## Triacylglycerol (51:3) levels against Malignant_melanoma_of_skin

Date: **04 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    6| 0.1276886| 0.2698970| 0.6608027|
|Weighted median           |    6| 0.2080470| 0.0833082| 0.0125137|
|Inverse variance weighted |    6| 0.1915374| 0.0792309| 0.0156293|
|Simple mode               |    6| 0.1796435| 0.1151304| 0.1794266|
|Weighted mode             |    6| 0.2344798| 0.0933964| 0.0537894|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 7.391027|    4| 0.1166116|
|Inverse variance weighted | 7.506704|    5| 0.1855996|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0104571| 0.0417936| 0.8147519|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004234|              0|TRUE                     |    0.0949196|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Triacylglycerol_513_levels_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Triacylglycerol_513_levels_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Triacylglycerol_513_levels_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Triacylglycerol_513_levels_against_Malignantmelanomaofskinchunk8-1.png)
