

# Two sample MR report

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## Concentration of medium VLDL particles against Malignant_melanoma_of_skin

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   13| 0.0249669| 0.1695866| 0.8856203|
|Weighted median           |   13| 0.2846880| 0.0840642| 0.0007078|
|Inverse variance weighted |   13| 0.2102886| 0.0726476| 0.0037959|
|Simple mode               |   13| 0.1297035| 0.1576110| 0.4265966|
|Weighted mode             |   13| 0.2598757| 0.1102493| 0.0362376|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 15.07626|   11| 0.1790323|
|Inverse variance weighted | 17.06464|   12| 0.1471818|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0232929| 0.0193386| 0.2536803|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002784|              0|TRUE                     |     0.035256|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Concentration_of_medium_VLDL_particles_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Concentration_of_medium_VLDL_particles_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Concentration_of_medium_VLDL_particles_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Concentration_of_medium_VLDL_particles_against_Malignantmelanomaofskinchunk8-1.png)
