

# Two sample MR report

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## Triacylglycerol (52:4) levels against Malignant_melanoma_of_skin

Date: **04 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    7| 0.2039089| 0.2078064| 0.3715352|
|Weighted median           |    7| 0.2044361| 0.0743905| 0.0059933|
|Inverse variance weighted |    7| 0.1692274| 0.0659334| 0.0102689|
|Simple mode               |    7| 0.1518725| 0.1041245| 0.1949632|
|Weighted mode             |    7| 0.2173017| 0.0834200| 0.0403952|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 7.662548|    5| 0.1758401|
|Inverse variance weighted | 7.711057|    6| 0.2600455|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0057986| 0.0325921| 0.8657747|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0006353|              0|TRUE                     |     0.039898|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Triacylglycerol_524_levels_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Triacylglycerol_524_levels_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Triacylglycerol_524_levels_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Triacylglycerol_524_levels_against_Malignantmelanomaofskinchunk8-1.png)
