

# Two sample MR report

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## Uridine against Malignant_melanoma_of_skin

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|       se|      pval|
|:-------------------------|----:|---------:|--------:|---------:|
|MR Egger                  |    3| -1.672078| 5.556999| 0.8139297|
|Weighted median           |    3|  1.900548| 1.412723| 0.1785256|
|Inverse variance weighted |    3|  2.908749| 1.147536| 0.0112519|
|Simple mode               |    3|  1.900955| 1.790950| 0.3997239|
|Weighted mode             |    3|  1.900955| 1.599919| 0.3567388|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.9329153|    1| 0.3341065|
|Inverse variance weighted | 1.6427112|    2| 0.4398350|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0517559| 0.0614318| 0.5542896|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001137|              0|TRUE                     |    0.3804024|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Uridine_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Uridine_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Uridine_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Uridine_against_Malignantmelanomaofskinchunk8-1.png)
