

# Two sample MR report

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## Triacylglycerol (52:2) levels against Malignant_melanoma_of_skin

Date: **04 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    4| 0.4152973| 0.2253321| 0.2066457|
|Weighted median           |    4| 0.2306318| 0.0880955| 0.0088453|
|Inverse variance weighted |    4| 0.2372745| 0.0759026| 0.0017718|
|Simple mode               |    4| 0.1835331| 0.1268921| 0.2438584|
|Weighted mode             |    4| 0.2912262| 0.1061031| 0.0710546|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0038203|    2| 0.9980917|
|Inverse variance weighted | 0.7078805|    3| 0.8713488|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0291617| 0.0347543| 0.4897339|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003369|              0|TRUE                     |    0.1350305|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Triacylglycerol_522_levels_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Triacylglycerol_522_levels_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Triacylglycerol_522_levels_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Triacylglycerol_522_levels_against_Malignantmelanomaofskinchunk8-1.png)
