

# Two sample MR report

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## 5alpha-androstan-3alpha,17alpha-diol monosulfate levels against Malignant_melanoma_of_skin

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6| -0.0507334| 0.0631387| 0.4667069|
|Weighted median           |    6| -0.0799907| 0.0420532| 0.0571542|
|Inverse variance weighted |    6| -0.0747213| 0.0336540| 0.0263997|
|Simple mode               |    6| -0.0840476| 0.0593544| 0.2159353|
|Weighted mode             |    6| -0.0850171| 0.0438625| 0.1103159|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.095979|    4| 0.7181112|
|Inverse variance weighted | 2.297605|    5| 0.8066185|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0085948| 0.0191409| 0.6766644|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0024469|              0|TRUE                     |    0.0003465|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/5alphaandrostan3alpha17alphadiol_monosulfate_levels_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/5alphaandrostan3alpha17alphadiol_monosulfate_levels_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/5alphaandrostan3alpha17alphadiol_monosulfate_levels_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/5alphaandrostan3alpha17alphadiol_monosulfate_levels_against_Malignantmelanomaofskinchunk8-1.png)
