

# Two sample MR report

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## Tyrosine to pyruvate ratio against Malignant_melanoma_of_skin

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.2527765| 0.2394591| 0.4827805|
|Weighted median           |    3| -0.2848728| 0.1362767| 0.0365819|
|Inverse variance weighted |    3| -0.3306112| 0.1144867| 0.0038798|
|Simple mode               |    3| -0.2614411| 0.1599157| 0.2436995|
|Weighted mode             |    3| -0.2630191| 0.1766752| 0.2749845|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.5348622|    1| 0.4645698|
|Inverse variance weighted | 0.6718231|    2| 0.7146863|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0105246| 0.0284384| 0.7743487|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.41e-05|              0|TRUE                     |    0.5251524|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Tyrosine_to_pyruvate_ratio_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Tyrosine_to_pyruvate_ratio_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Tyrosine_to_pyruvate_ratio_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Tyrosine_to_pyruvate_ratio_against_Malignantmelanomaofskinchunk8-1.png)
