

# Two sample MR report

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## Triacylglycerol (52:3) levels against Malignant_melanoma_of_skin

Date: **04 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    6| 0.2869557| 0.1597823| 0.1469350|
|Weighted median           |    6| 0.2016726| 0.0751268| 0.0072654|
|Inverse variance weighted |    6| 0.1962502| 0.0582534| 0.0007547|
|Simple mode               |    6| 0.1550103| 0.1137246| 0.2310440|
|Weighted mode             |    6| 0.2128524| 0.0854321| 0.0550613|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.675402|    4| 0.6135258|
|Inverse variance weighted | 3.047065|    5| 0.6927298|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|        -0.01557| 0.0255396| 0.5750307|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0007295|              0|TRUE                     |    0.0276414|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Triacylglycerol_523_levels_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Triacylglycerol_523_levels_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Triacylglycerol_523_levels_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Triacylglycerol_523_levels_against_Malignantmelanomaofskinchunk8-1.png)
