

# Two sample MR report

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## Triglycerides in small VLDL against Malignant_melanoma_of_skin

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   13| 0.1102129| 0.1664854| 0.5216000|
|Weighted median           |   13| 0.2537618| 0.0817546| 0.0019096|
|Inverse variance weighted |   13| 0.1700062| 0.0628484| 0.0068300|
|Simple mode               |   13| 0.2860390| 0.1640196| 0.1067068|
|Weighted mode             |   13| 0.2891287| 0.1069652| 0.0192019|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 14.27801|   11| 0.2179900|
|Inverse variance weighted | 14.47576|   12| 0.2713638|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0078737| 0.0201723| 0.7037521|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000302|              0|TRUE                     |    0.0227706|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Triglycerides_in_small_VLDL_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Triglycerides_in_small_VLDL_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Triglycerides_in_small_VLDL_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Triglycerides_in_small_VLDL_against_Malignantmelanomaofskinchunk8-1.png)
