

# Two sample MR report

---

## Cholesterol esters in large VLDL against Malignant_melanoma_of_skin

Date: **03 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   11| 0.1278731| 0.1901438| 0.5181523|
|Weighted median           |   11| 0.2301733| 0.0924306| 0.0127661|
|Inverse variance weighted |   11| 0.1688690| 0.0771300| 0.0285673|
|Simple mode               |   11| 0.2082926| 0.1783810| 0.2700211|
|Weighted mode             |   11| 0.2879844| 0.1116541| 0.0274513|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 13.45569|    9| 0.1430474|
|Inverse variance weighted | 13.54062|   10| 0.1949950|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0053277| 0.0223533| 0.8169554|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000215|              0|TRUE                     |    0.0659654|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Cholesterol_esters_in_large_VLDL_against_Malignantmelanomaofskinchunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Cholesterol_esters_in_large_VLDL_against_Malignantmelanomaofskinchunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/Cholesterol_esters_in_large_VLDL_against_Malignantmelanomaofskinchunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Cholesterol_esters_in_large_VLDL_against_Malignantmelanomaofskinchunk8-1.png)
