

# Two sample MR report

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## Total lipids in medium VLDL against Malignant_melanoma_of_skin

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   11| 0.0988181| 0.1718270| 0.5793133|
|Weighted median           |   11| 0.2414479| 0.0850822| 0.0045423|
|Inverse variance weighted |   11| 0.1886792| 0.0711211| 0.0079797|
|Simple mode               |   11| 0.2028048| 0.1568656| 0.2251312|
|Weighted mode             |   11| 0.2626907| 0.1009539| 0.0263969|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 12.29493|    9| 0.1971888|
|Inverse variance weighted | 12.75254|   10| 0.2378384|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0119871| 0.0207111| 0.5769366|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002796|              0|TRUE                     |    0.0346595|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Total_lipids_in_medium_VLDL_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Total_lipids_in_medium_VLDL_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Total_lipids_in_medium_VLDL_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Total_lipids_in_medium_VLDL_against_Malignantmelanomaofskinchunk8-1.png)
