

# Two sample MR report

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## 1-stearoyl-2-arachidonoyl-GPI (18:0/20:4) levels against Malignant_melanoma_of_skin

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    7| 0.1419364| 0.1445206| 0.3711442|
|Weighted median           |    7| 0.0959138| 0.0676029| 0.1559627|
|Inverse variance weighted |    7| 0.1247167| 0.0558692| 0.0255953|
|Simple mode               |    7| 0.2416090| 0.1378909| 0.1302979|
|Weighted mode             |    7| 0.0539339| 0.0700379| 0.4704823|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 6.539725|    5| 0.2571822|
|Inverse variance weighted | 6.562334|    6| 0.3632227|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.0032495| 0.0247152| 0.900525|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.001429|              0|TRUE                     |    0.0010657|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/1stearoyl2arachidonoylGPI_180204_levels_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/1stearoyl2arachidonoylGPI_180204_levels_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/1stearoyl2arachidonoylGPI_180204_levels_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/1stearoyl2arachidonoylGPI_180204_levels_against_Malignantmelanomaofskinchunk8-1.png)
