

# Two sample MR report

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## Uridine to pseudouridine ratio against Malignant_melanoma_of_skin

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -1.7791561| 1.6203224| 0.4702769|
|Weighted median           |    3|  0.1554900| 0.1505277| 0.3016197|
|Inverse variance weighted |    3|  0.2972368| 0.1320583| 0.0243982|
|Simple mode               |    3|  0.1534995| 0.2059886| 0.5338317|
|Weighted mode             |    3|  0.1534995| 0.2012416| 0.5252912|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.9629472|    1| 0.3264454|
|Inverse variance weighted | 2.6135001|    2| 0.2706984|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.2237077| 0.1741271| 0.4210674|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001116|              0|TRUE                     |     0.360188|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Uridine_to_pseudouridine_ratio_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Uridine_to_pseudouridine_ratio_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Uridine_to_pseudouridine_ratio_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Uridine_to_pseudouridine_ratio_against_Malignantmelanomaofskinchunk8-1.png)
