

# Two sample MR report

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## Triacylglycerol (54:6) levels against Malignant_melanoma_of_skin

Date: **04 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    3| 0.4977067| 0.2611541| 0.3076296|
|Weighted median           |    3| 0.2527336| 0.1050905| 0.0161763|
|Inverse variance weighted |    3| 0.2594688| 0.0892293| 0.0036388|
|Simple mode               |    3| 0.1728115| 0.1353486| 0.3298772|
|Weighted mode             |    3| 0.3218628| 0.1206988| 0.1165482|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0069098|    1| 0.9337519|
|Inverse variance weighted | 0.9491018|    2| 0.6221644|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|      -0.0349003| 0.035955| 0.5094757|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002081|              0|TRUE                     |    0.2439108|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Triacylglycerol_546_levels_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Triacylglycerol_546_levels_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Triacylglycerol_546_levels_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Triacylglycerol_546_levels_against_Malignantmelanomaofskinchunk8-1.png)
