

# Two sample MR report

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## Androstenediol (3beta,17beta) monosulfate (2) levels against Malignant_melanoma_of_skin

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.2207375| 0.1711972| 0.3262616|
|Weighted median           |    4| -0.2007702| 0.0916681| 0.0285106|
|Inverse variance weighted |    4| -0.1560715| 0.0753592| 0.0383556|
|Simple mode               |    4| -0.2408269| 0.1348222| 0.1720340|
|Weighted mode             |    4| -0.2029586| 0.1023211| 0.1415686|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.746762|    2| 0.2532493|
|Inverse variance weighted | 3.013341|    3| 0.3895729|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0115079| 0.0261203| 0.7025674|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001407|              0|TRUE                     |    0.3146578|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Androstenediol_3beta17beta_monosulfate_2_levels_against_Malignantmelanomaofskinchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Androstenediol_3beta17beta_monosulfate_2_levels_against_Malignantmelanomaofskinchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Androstenediol_3beta17beta_monosulfate_2_levels_against_Malignantmelanomaofskinchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Androstenediol_3beta17beta_monosulfate_2_levels_against_Malignantmelanomaofskinchunk8-1.png)
