Two sample MR report
Diacylglycerol (18:1_18:1) levels against Malignant_melanoma_of_skin
Date: 04 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | 0.2278977 | 0.1986755 | 0.3345355 |
| Weighted median | 5 | 0.2660430 | 0.0878299 | 0.0024531 |
| Inverse variance weighted | 5 | 0.2961734 | 0.0690335 | 0.0000178 |
| Simple mode | 5 | 0.2339904 | 0.1136193 | 0.1085233 |
| Weighted mode | 5 | 0.2535933 | 0.1021263 | 0.0679823 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.181912 | 3 | 0.5355200 |
| Inverse variance weighted | 2.316226 | 4 | 0.6778163 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0112892 | 0.0308036 | 0.738322 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004315 | 0 | TRUE | 0.097306 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
