Two sample MR report
Diacylglycerol (18:1_18:2) levels against Malignant_melanoma_of_skin
Date: 04 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 0.3513038 | 0.1529878 | 0.0832787 |
| Weighted median | 6 | 0.1797703 | 0.0752319 | 0.0168690 |
| Inverse variance weighted | 6 | 0.1785973 | 0.0598222 | 0.0028314 |
| Simple mode | 6 | 0.1813585 | 0.1080651 | 0.1541419 |
| Weighted mode | 6 | 0.2249873 | 0.0804386 | 0.0381281 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.5640279 | 4 | 0.9669759 |
| Inverse variance weighted | 2.0684497 | 5 | 0.8395950 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.032461 | 0.0264653 | 0.2872545 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0006629 | 0 | TRUE | 0.0432205 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
