Two sample MR report
Phosphatidylcholine (18:0_20:3) levels against Malignant_melanoma_of_skin
Date: 04 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.5234128 | 0.2680019 | 0.3012634 |
| Weighted median | 3 | 0.2180163 | 0.0845451 | 0.0099174 |
| Inverse variance weighted | 3 | 0.2205156 | 0.0720522 | 0.0022097 |
| Simple mode | 3 | 0.1760112 | 0.1155723 | 0.2672167 |
| Weighted mode | 3 | 0.2089531 | 0.1131837 | 0.2061526 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.447781 | 1 | 0.5033906 |
| Inverse variance weighted | 1.824667 | 2 | 0.4015860 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0562782 | 0.0479613 | 0.4493139 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004644 | 0 | TRUE | 0.0791316 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
