Two sample MR report
Phosphatidylcholine (O-16:0_20:3) levels against Malignant_melanoma_of_skin
Date: 04 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.3241228 | 0.3045313 | 0.4801666 |
| Weighted median | 3 | 0.2667610 | 0.0907731 | 0.0032952 |
| Inverse variance weighted | 3 | 0.2767157 | 0.0777523 | 0.0003724 |
| Simple mode | 3 | 0.2614829 | 0.1075437 | 0.1355859 |
| Weighted mode | 3 | 0.2631650 | 0.1003371 | 0.1197996 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.1369120 | 1 | 0.7113704 |
| Inverse variance weighted | 0.1628357 | 2 | 0.9218084 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0098522 | 0.0611904 | 0.898371 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003502 | 0 | TRUE | 0.1395182 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
