Two sample MR report
X-12063 against Malignant_melanoma_of_skin
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 0.2031213 | 0.1877082 | 0.3400783 |
| Weighted median | 6 | 0.2517590 | 0.1326819 | 0.0577668 |
| Inverse variance weighted | 6 | 0.2778361 | 0.1185041 | 0.0190513 |
| Simple mode | 6 | 0.1950754 | 0.1987993 | 0.3715246 |
| Weighted mode | 6 | 0.2466290 | 0.1356812 | 0.1287881 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.9545604 | 4 | 0.9166060 |
| Inverse variance weighted | 1.2179861 | 5 | 0.9431402 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0083211 | 0.0162125 | 0.6348234 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0069243 | 0 | TRUE | 0 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
