Two sample MR report
Cholesterol esters in large VLDL against Malignant_melanoma_of_skin
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 11 | 0.1278731 | 0.1901438 | 0.5181523 |
| Weighted median | 11 | 0.2301733 | 0.0924306 | 0.0127661 |
| Inverse variance weighted | 11 | 0.1688690 | 0.0771300 | 0.0285673 |
| Simple mode | 11 | 0.2082926 | 0.1783810 | 0.2700211 |
| Weighted mode | 11 | 0.2879844 | 0.1116541 | 0.0274513 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 13.45569 | 9 | 0.1430474 |
| Inverse variance weighted | 13.54062 | 10 | 0.1949950 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0053277 | 0.0223533 | 0.8169554 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.000215 | 0 | TRUE | 0.0659654 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
