Two sample MR report
Free cholesterol in large VLDL against Malignant_melanoma_of_skin
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 10 | 0.4013226 | 0.2378606 | 0.1300428 |
| Weighted median | 10 | 0.2241947 | 0.0941328 | 0.0172336 |
| Inverse variance weighted | 10 | 0.1767955 | 0.0819320 | 0.0309408 |
| Simple mode | 10 | 0.2239900 | 0.1812549 | 0.2478250 |
| Weighted mode | 10 | 0.2831398 | 0.1179466 | 0.0398603 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 10.93770 | 8 | 0.2052540 |
| Inverse variance weighted | 12.31971 | 9 | 0.1958798 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0288859 | 0.0287309 | 0.3441444 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001744 | 0 | TRUE | 0.0838837 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
