Two sample MR report
Concentration of large VLDL particles against Malignant_melanoma_of_skin
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 10 | 0.1274372 | 0.2060649 | 0.5534860 |
| Weighted median | 10 | 0.2607674 | 0.0944856 | 0.0057826 |
| Inverse variance weighted | 10 | 0.1983916 | 0.0771108 | 0.0100875 |
| Simple mode | 10 | 0.2641422 | 0.1684614 | 0.1513327 |
| Weighted mode | 10 | 0.2926778 | 0.1125251 | 0.0286911 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 11.12972 | 8 | 0.1944570 |
| Inverse variance weighted | 11.32488 | 9 | 0.2540957 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0085873 | 0.0229274 | 0.7177344 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002093 | 0 | TRUE | 0.0696277 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
