Two sample MR report
Total cholesterol in medium VLDL against Malignant_melanoma_of_skin
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 15 | 0.2587685 | 0.1542487 | 0.1172885 |
| Weighted median | 15 | 0.2262406 | 0.0791911 | 0.0042781 |
| Inverse variance weighted | 15 | 0.1497970 | 0.0569665 | 0.0085494 |
| Simple mode | 15 | 0.2448163 | 0.1402232 | 0.1027234 |
| Weighted mode | 15 | 0.2751205 | 0.0972339 | 0.0133807 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 14.28729 | 13 | 0.3539271 |
| Inverse variance weighted | 14.92555 | 14 | 0.3832628 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0137293 | 0.0180158 | 0.4596218 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002913 | 0 | TRUE | 0.0257096 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
