Two sample MR report
Free cholesterol in medium VLDL against Malignant_melanoma_of_skin
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 11 | 0.2851670 | 0.1722088 | 0.1321170 |
| Weighted median | 11 | 0.2644034 | 0.0849450 | 0.0018542 |
| Inverse variance weighted | 11 | 0.2016108 | 0.0685872 | 0.0032876 |
| Simple mode | 11 | 0.2415545 | 0.1492014 | 0.1365205 |
| Weighted mode | 11 | 0.2760359 | 0.1133485 | 0.0351312 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 11.72044 | 9 | 0.2295325 |
| Inverse variance weighted | 12.09020 | 10 | 0.2790653 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0102361 | 0.01921 | 0.6070378 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002698 | 0 | TRUE | 0.0307205 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
